A Voltammetric Method for the Quantitative Determination of Midecamycin Compared to Its Simultaneous HPLC Determination
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AuthorsDrljevic-Djuric, K. M.
Avramov Ivić, Milka
Petrović, Slobodan D.
Article (Published version)
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The aim of this study was to present the quantitative determination of midecamycin at a gold electrode in 0.05 M NaHCO(3) using cyclic linear sweep voltammetry. It was found that the value of the oxidative peak of pure midecamycin at 0.85 V vs. SCE at a scan rate of 50 mV s(-1) is a linear function of the concentration in the range 0.1693-0.3289 mg cm(-3). The value of its reductive peak at 0.3 V vs. SCE is a linear function of the concentration in the range 0.11396-0.3802 mg cm(-3). HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the current peak values concerning the correlation with each investigated concentration of midecamycin. By MS spectrometry no degradation products were found in electrolyte during its quantitative determination.
Keywords:midecamycin / gold electrode / quantitative determination / HPLC / MS spectrometry
Source:Russian Journal of Electrochemistry, 2011, 47, 7, 781-786
- Maik Nauka/Interperiodica/Springer, New York