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Ekstrakt lista masline moduliše oksidativne promene indukovane imobilizacionim stresom ubrzanim hladnoćom u jetri pacova

dc.creatorDekanski, Dragana
dc.creatorRistić, Slavica S.
dc.creatorRadonjic, Nevena V.
dc.creatorPetronijevic, Natasa D.
dc.creatorDekanski, Aleksandar
dc.creatorMitrovic, Dusan M.
dc.date.accessioned2019-01-30T17:27:03Z
dc.date.available2019-01-30T17:27:03Z
dc.date.issued2011
dc.identifier.issn0352-5139
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/845
dc.description.abstractRecently, the beneficial effects of different single doses of standardized dry olive (Olea europaea L.) leaf extract (OLE) in cold restraint stress (CRS)-induced gastric lesions in rats and its influence on oxidative parameters in gastric mucosa were demonstrated. The present study was undertaken to investigate the long-term pretreatment efficacy of OLE and its potential in the modulation of CRS- induced oxidative changes at the liver level. The experimental animals were divided into four groups, i.e., control, OLE-treated, CRS non-treated and CRS treated with OLE (CRS+OLE) groups. CRS caused severe gastric lesions in all non-pretreated animals and two-week pretreatment with OLE (80 mg per kg of body weight) attenuated stress-induced gastric lesions significantly. The malondialdehyde (MDA) level as an index of lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activities were measured spectrophotometrically in liver tissue homogenates. The MDA level was increased in the CRS group and significantly decreased in the CRS+OLE group. The SOD and CAT activities were significantly decreased in the CRS group. In the CRS+OLE group, the activities of these two enzymes were significantly increased in comparison with the CRS group. The results obtained indicate that long-term supplementation with OLE provides oxidant/antioxidant balance in liver during stress condition.en
dc.description.abstractNedavno su pokazani povoljni efekti različitih pojedinačnih doza standardizovanog ekstrakta lista masline (Olea europaea L.) na želudačne lezije pacova indukovane imobilizacionim stresom ubrzanim hladnoćom (CRS) i njegov uticaj na parametre oksidativnog stresa u želudačnoj sluznici. U ovoj studiji ispitivan je efekat dugotrajnog pretretmana listom masline i njegov potencijal u modulaciji CRS-om indukovanih oksidativnih promena na nivou jetre. Eksperimentalne životinje su podeljene u četiri grupe: kontrolna, tretirana ekstraktom lista masline (OLE), CRS i grupa kod koje je CRS tretiran ekstraktom (CRS+OLE). CRS je prouzrokovao ozbiljna oštećenja želuca kod svih nepretretiranih životinja, a dvonedeljni pretretman sa OLE (80 mg kg-1 t.t.) značajno je smanjio stresom indukovane želudačne lezije. Malondialdehid (MDA), kao pokazatelj lipidne peroksidacije, aktivnosti superoksid-dismutaze (SOD) i katalaze (CAT) mereni su spektrofotometrijski u homogenatima tkiva jetre. Nivo MDA se značajno povećao u CRS grupi, a potom značajno smanjio u CRS+OLE grupi. Aktivnosti SOD i CAT bile su značajno smanjene u CRS grupi, dok je u CRS+OLE grupi životinja aktivnost ova dva enzima znatno povećana u poređenju sa CRS grupom. Dobijeni rezultati ukazuju na to da dugotrajno prehranjivanje ekstraktom lista masline pomaže uspostavljanje oksidativne-antioksidativne ravnoteže u jetri tokom stresa.sr
dc.publisherSerbian Chemical Society
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175096/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subjectolive leafen
dc.subjectcold restraint stressen
dc.subjectoxidative stressen
dc.subjectliveren
dc.titleOlive leaf extract modulates cold restraint stress-induced oxidative changes in rat liveren
dc.titleEkstrakt lista masline moduliše oksidativne promene indukovane imobilizacionim stresom ubrzanim hladnoćom u jetri pacovasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractДекански, Aлександар; Ристиц, Славица; Петронијевиц, Натаса Д.; Митровиц, Дусан М.; Радоњиц, Невена В.; Декански, Драгана; Екстракт листа маслине модулише оксидативне промене индуковане имобилизационим стресом убрзаним хладноћом у јетри пацова; Екстракт листа маслине модулише оксидативне промене индуковане имобилизационим стресом убрзаним хладноћом у јетри пацова;
dc.citation.volume76
dc.citation.issue9
dc.citation.spage1207
dc.citation.epage1218
dc.citation.other76(9): 1207-1218
dc.citation.rankM23
dc.identifier.doi10.2298/JSC110204107D
dc.identifier.rcubConv_2669
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/9439/843.pdf
dc.identifier.scopus2-s2.0-80053106662
dc.identifier.wos000295659800003
dc.type.versionpublishedVersion


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