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dc.creatorVujic, Jelena M.
dc.creatorKaluđerović, Goran N.
dc.creatorMilovanovic, Marija
dc.creatorZmejkovski, Bojana
dc.creatorVolarevic, Vladislav
dc.creatorZivic, Danijela
dc.creatorDurdevic, Predrag
dc.creatorArsenijevic, Nebojsa
dc.creatorTrifunovic, Srecko R.
dc.date.accessioned2019-01-30T17:26:52Z
dc.date.available2019-01-30T17:26:52Z
dc.date.issued2011
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/838
dc.description.abstractPlatinum(II) complexes (1-4) with bidentate N,N'-ligands, O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid were synthesized and characterized by IR, (1)H NMR and (13)C NMR spectroscopy and elemental analysis. DFT calculations were performed for the complexes and it was found that only one diastereoisomer could be formed. Cytotoxic activity of complexes 1-4 was determined against chronic lymphocytic leukemia cells (CLL) and compared to the activity of ligand precursors L1 center dot 2HCl-L4 center dot 2HCl and corresponding palladium(II) complexes, [PdCl(2)L] (L = L1-L4). The complexes were found to exhibit significantly higher antitumor activities than cisplatin on CLL cells. Cytotoxic effect of platinum(II) complexes on CLL cells was higher compared to corresponding palladium(II) complexes. In addition the mode of cell death induced by platinum(II) complexes was determined.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175069/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationEC
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectPlatinum(II) complexesen
dc.subjectEdda-type ligandsen
dc.subjectAntitumoral activityen
dc.subjectChronic lymphocytic leukemia cellsen
dc.titleStereospecific ligands and their complexes. Part VII. Synthesis, characterization and in vitro antitumoral activity of platinum(II) complexes with O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)pentanoic aciden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВујиц, Јелена М.; Aрсенијевиц, Небојса; Змејковски, Бојана; Калудеровиц, Горан Н.; Трифуновиц, Срецко Р.; Воларевиц, Владислав; Миловановиц, Марија; Зивиц, Данијела; Дурдевиц, Предраг;
dc.citation.volume46
dc.citation.issue9
dc.citation.spage4559
dc.citation.epage4565
dc.citation.other46(9): 4559-4565
dc.citation.rankM21
dc.identifier.pmid21840630
dc.identifier.doi10.1016/j.ejmech.2011.07.034
dc.identifier.rcubConv_2661
dc.identifier.scopus2-s2.0-80052931979
dc.identifier.wos000295237400109
dc.type.versionpublishedVersion


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