Bench-to-bedside review: Sepsis - from the redox point of view
Апстракт
The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and septic shock have been the subject of investigations for nearly half a century. Controversies still exist with regard to understanding the molecular pathophysiology of sepsis in relation to the complex roles played by reactive oxygen species, nitric oxide, complements and cytokines. In the present review we categorise the key turning points in sepsis development and outline the most probable sequence of events leading to cellular dysfunction and organ failure under septic conditions. We have applied an integrative approach in order to fuse current state-of-the-art knowledge about redox processes involving hydrogen peroxide, nitric oxide, superoxide, peroxynitrite and hydroxyl radical, which lead to mitochondrial respiratory dysfunction. Finally, from this point of view, the potential of redox therapy targeting sepsis is discussed.
Извор:
Critical Care, 2011, 15, 5Издавач:
- Biomed Central Ltd, London
Финансирање / пројекти:
- Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-MESTD-Basic Research (BR or ON)-173014)
- Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
DOI: 10.1186/cc10334
ISSN: 1466-609X
PubMed: 21996422
WoS: 000303048200073
Scopus: 2-s2.0-80054678294
Институција/група
IHTMTY - JOUR AU - Andrades, Michael Everton AU - Morina, Arian AU - Spasić, Snežana AU - Spasojević, Ivan PY - 2011 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/822 AB - The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and septic shock have been the subject of investigations for nearly half a century. Controversies still exist with regard to understanding the molecular pathophysiology of sepsis in relation to the complex roles played by reactive oxygen species, nitric oxide, complements and cytokines. In the present review we categorise the key turning points in sepsis development and outline the most probable sequence of events leading to cellular dysfunction and organ failure under septic conditions. We have applied an integrative approach in order to fuse current state-of-the-art knowledge about redox processes involving hydrogen peroxide, nitric oxide, superoxide, peroxynitrite and hydroxyl radical, which lead to mitochondrial respiratory dysfunction. Finally, from this point of view, the potential of redox therapy targeting sepsis is discussed. PB - Biomed Central Ltd, London T2 - Critical Care T1 - Bench-to-bedside review: Sepsis - from the redox point of view VL - 15 IS - 5 DO - 10.1186/cc10334 ER -
@article{ author = "Andrades, Michael Everton and Morina, Arian and Spasić, Snežana and Spasojević, Ivan", year = "2011", abstract = "The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and septic shock have been the subject of investigations for nearly half a century. Controversies still exist with regard to understanding the molecular pathophysiology of sepsis in relation to the complex roles played by reactive oxygen species, nitric oxide, complements and cytokines. In the present review we categorise the key turning points in sepsis development and outline the most probable sequence of events leading to cellular dysfunction and organ failure under septic conditions. We have applied an integrative approach in order to fuse current state-of-the-art knowledge about redox processes involving hydrogen peroxide, nitric oxide, superoxide, peroxynitrite and hydroxyl radical, which lead to mitochondrial respiratory dysfunction. Finally, from this point of view, the potential of redox therapy targeting sepsis is discussed.", publisher = "Biomed Central Ltd, London", journal = "Critical Care", title = "Bench-to-bedside review: Sepsis - from the redox point of view", volume = "15", number = "5", doi = "10.1186/cc10334" }
Andrades, M. E., Morina, A., Spasić, S.,& Spasojević, I.. (2011). Bench-to-bedside review: Sepsis - from the redox point of view. in Critical Care Biomed Central Ltd, London., 15(5). https://doi.org/10.1186/cc10334
Andrades ME, Morina A, Spasić S, Spasojević I. Bench-to-bedside review: Sepsis - from the redox point of view. in Critical Care. 2011;15(5). doi:10.1186/cc10334 .
Andrades, Michael Everton, Morina, Arian, Spasić, Snežana, Spasojević, Ivan, "Bench-to-bedside review: Sepsis - from the redox point of view" in Critical Care, 15, no. 5 (2011), https://doi.org/10.1186/cc10334 . .