Intramolecular Barbier reaction in water: Cyclopentane and cyclohexane ring closure

Abstract

Zinc or indium promoted intramolecular Barbier reactions of aldehydes containing a suitably positioned allylic or propargylic halide unit afford unsaturated cyclic alcohols in moderate yields.

Aldehidi koji u pogodnom položaju poseduju alil-halogenidnu ili propargil halogenidnu strukturnu jedinicu reaguju u vodenim uslovima sa cinkom ili indijumom, pri čemu nastaju nezasićeni ciklični alkoholi u umerenim prinosima.