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dc.creatorMarkovic, Violeta
dc.creatorErić, Slavica
dc.creatorStanojković, Tatjana
dc.creatorGligorijević, Nevenka
dc.creatorArandelovic, Sandra
dc.creatorTodorović, Nina
dc.creatorTrifunović, Snežana
dc.creatorManojlović, Nedeljko
dc.creatorJelić, Ratomir
dc.creatorJoksovic, Milan D.
dc.date.accessioned2019-01-30T17:25:49Z
dc.date.available2019-01-30T17:25:49Z
dc.date.issued2011
dc.identifier.issn0960-894X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/791
dc.description.abstractTwenty five 4-aminomethylidene derivatives obtained from 3-phenyl-2-pyrazolin-5-one and 1,3-diphenyl-2-pyrazolin-5-one were synthesized and tested for their antiproliferative activity against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The compounds derived from 1,3-diphenyl-2-pyrazolin-5-one exhibited the most remarkable activity in the treatment of both cell lines. In vitro antiproliferative activities were accompanied by an important apoptotic fraction of both cell lines; also, compounds inhibited key endothelial cell functions implicated in invasion and angiogenesis. QSAR methods were performed in order to analyze the influence of structural features of the compounds investigated on the antiproliferative potential on MDA-MB-361 and MDA-MB-453 cancer cells. One-parameter heuristic analysis was performed and different whole molecule and fragmental descriptors were considered for rationalization of mechanism of interaction of these compounds with active place of hypothetical target included in tumorigenesis.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsrestrictedAccess
dc.sourceBioorganic and Medicinal Chemistry Letters
dc.subjectPyrazolonesen
dc.subjectAntiproliferative activityen
dc.subjectBreast canceren
dc.subjectAngiogenesisen
dc.subjectQSAR studiesen
dc.titleAntiproliferative activity and QSAR studies of a series of new 4-aminomethylidene derivatives of some pyrazol-5-onesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМанојловиц, Недељко; Aранделовиц, Сандра; Тодоровић, Нина; Ериц, Славица; Марковиц, Виолета; Јелиц, Ратомир; Трифуновиц, Снезана; Јоксовиц, Милан Д.; Станојковиц, Татјана; Глигоријевиц, Невенка;
dc.citation.volume21
dc.citation.issue15
dc.citation.spage4416
dc.citation.epage4421
dc.citation.other21(15): 4416-4421
dc.citation.rankM22
dc.identifier.pmid21733686
dc.identifier.doi10.1016/j.bmcl.2011.06.025
dc.identifier.rcubConv_2631
dc.identifier.scopus2-s2.0-79960347940
dc.identifier.wos000292729900008
dc.type.versionpublishedVersion


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