Приказ основних података о документу
Relevance of the ability of fructose 1,6-bis(phosphate) to sequester ferrous but not ferric ions
dc.creator | Bajic, Aleksandar | |
dc.creator | Zakrzewska, Joanna | |
dc.creator | Gođevac, Dejan | |
dc.creator | Anđus, Pavle | |
dc.creator | Jones, David R. | |
dc.creator | Spasić, Mihajlo | |
dc.creator | Spasojević, Ivan | |
dc.date.accessioned | 2019-01-30T17:25:35Z | |
dc.date.available | 2019-01-30T17:25:35Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0008-6215 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/781 | |
dc.description.abstract | The cytoprotective activity of F16BP has been documented in severe conditions such as convulsions, reperfusion injury, septic shock, diabetic complications, hypothermia-induced injury, UV-provoked skin damage and in other processes including apoptosis and excitotoxicity. F16BP shows very efficient cytoprotective activity in astroglial cells exposed to H2O2-provoked oxidative stress and during neuronal injury caused by hypoxic conditions. As most of the aforementioned processes involve iron activity-related conditions, we investigated the ferric and ferrous iron binding properties of F16BP under physiological conditions using P-31 NMR and EPR spectroscopy. Our results indicate that cytoprotective F16BP activity is predominantly based on ferrous iron sequestration. P-31 NMR spectroscopy of F16BP employing paramagnetic properties of iron clearly showed that F16BP forms stabile complexes with Fe2+ which was verified by EPR of another divalent cation-Mn2+. On the other hand, F16BP does not sequester ferric iron nor does it increase its redox activity as shown by P-31 NMR and EPR spin-trapping. Therefore, F16BP may be beneficial in neurodegenerative and other conditions that are characterised by ferric iron stores and deposits. | en |
dc.publisher | Elsevier Sci Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS// | |
dc.rights | restrictedAccess | |
dc.source | Carbohydrate Research | |
dc.subject | Fructose 1,6-bis(phosphate) | en |
dc.subject | Chelation | en |
dc.subject | Iron | en |
dc.subject | Cerebrospinal fluid | en |
dc.subject | EPR | en |
dc.subject | P-31 NMR | en |
dc.title | Relevance of the ability of fructose 1,6-bis(phosphate) to sequester ferrous but not ferric ions | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Закрзеwска, Јоанна; Спасојевиц, Иван; Гођевац, Дејан; Јонес, Давид Р.; Бајиц, Aлександар; Aнђус, Павле; Спасиц, Михајло; | |
dc.citation.volume | 346 | |
dc.citation.issue | 3 | |
dc.citation.spage | 416 | |
dc.citation.epage | 420 | |
dc.citation.other | 346(3): 416-420 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 21232735 | |
dc.identifier.doi | 10.1016/j.carres.2010.12.008 | |
dc.identifier.scopus | 2-s2.0-79951510026 | |
dc.identifier.wos | 000293037400005 | |
dc.type.version | publishedVersion |