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Relevance of the ability of fructose 1,6-bis(phosphate) to sequester ferrous but not ferric ions

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2011
Authors
Bajic, Aleksandar
Zakrzewska, Joanna
Gođevac, Dejan
Anđus, Pavle
Jones, David R.
Spasic, Mihajlo
Spasojević, Ivan
Article (Published version)
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Abstract
The cytoprotective activity of F16BP has been documented in severe conditions such as convulsions, reperfusion injury, septic shock, diabetic complications, hypothermia-induced injury, UV-provoked skin damage and in other processes including apoptosis and excitotoxicity. F16BP shows very efficient cytoprotective activity in astroglial cells exposed to H2O2-provoked oxidative stress and during neuronal injury caused by hypoxic conditions. As most of the aforementioned processes involve iron activity-related conditions, we investigated the ferric and ferrous iron binding properties of F16BP under physiological conditions using P-31 NMR and EPR spectroscopy. Our results indicate that cytoprotective F16BP activity is predominantly based on ferrous iron sequestration. P-31 NMR spectroscopy of F16BP employing paramagnetic properties of iron clearly showed that F16BP forms stabile complexes with Fe2+ which was verified by EPR of another divalent cation-Mn2+. On the other hand, F16BP does not ...sequester ferric iron nor does it increase its redox activity as shown by P-31 NMR and EPR spin-trapping. Therefore, F16BP may be beneficial in neurodegenerative and other conditions that are characterised by ferric iron stores and deposits.

Keywords:
Fructose 1,6-bis(phosphate) / Chelation / Iron / Cerebrospinal fluid / EPR / P-31 NMR
Source:
Carbohydrate Research, 2011, 346, 3, 416-420
Publisher:
  • Elsevier Sci Ltd, Oxford
Projects:
  • Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology (RS-173014)
  • The membranes as sites of interaction between the intracellular and apoplastic environments: studies of the bioenergetics and signaling using biophysical and biochemical techniques. (RS-173040)

DOI: 10.1016/j.carres.2010.12.008

ISSN: 0008-6215

PubMed: 21232735

WoS: 000293037400005

Scopus: 2-s2.0-79951510026
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/781
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IHTM

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