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dc.creatorMarković, Vladimir M.
dc.creatorČupić, Željko
dc.creatorVukojevic, Vladana
dc.creatorKolar-Anić, Ljiljana
dc.date.accessioned2019-01-30T17:25:32Z
dc.date.available2019-01-30T17:25:32Z
dc.date.issued2011
dc.identifier.issn0918-8959
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/779
dc.description.abstractDetailed dynamics of the hypothalamic-pituitary-adrenal (I-IPA) axis is complex, depending on the individual metabolic load of an organism, its current status (healthy/ill, circadian phase (day/night), ultradian phase) and environmental impact. Therefore, it is difficult to compare the HPA axis activity between different individuals or draw unequivocal conclusions about the overall status of the HPA axis in an individual using single time-point measurements of cortisol levels. The aim of this study is to identify parameters that enable us to compare different dynamic states of the HPA axis and use them to investigate self-regulation mechanisms in the HPA axis under acute and chronic stress. In this regard, a four-dimensional stoichiometric model of the HPA axis was used. Acute stress was modeled by inducing an abrupt change in cortisol level during the course of numerical integration, whereas chronic stress was modeled by changing the mean stationary state concentrations of CRH. Effects of acute stress intensity, duration and time of onset with respect to the ultradian amplitude, ultradian phase and the circadian phase of the perturbed oscillation were studied in detail. Bifurcation analysis was used to predict the response of the HPA axis to chronic stress. Model predictions were compared with experimental findings reported in the literature and relevance for pharmacotherapy with glucocorticoids was discussed.en
dc.publisherJapan Endocrine Soc, Kyoto
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45001/RS//
dc.relationSwedish Research Council
dc.relationSwedish Brain Foundation
dc.relationKnut and Alice Wallenberg Foundation
dc.rightsopenAccess
dc.sourceEndocrine Journal
dc.subjectHPA axisen
dc.subjectStressen
dc.subjectCortisolen
dc.subjectPredictive modelingen
dc.subjectCircadian and ultradian rhythmicityen
dc.titlePredictive modeling of the hypothalamic-pituitary-adrenal (HPA) axis response to acute and chronic stressen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМарковиц, Владимир М.; Вукојевиц, Владана; Чупић, Жељко; Колар-Aниц, Љиљана;
dc.citation.volume58
dc.citation.issue10
dc.citation.spage889
dc.citation.epage904
dc.citation.other58(10): 889-904
dc.citation.rankM23
dc.identifier.pmid21852742
dc.identifier.doi10.1507/endocrj.EJ11-0037
dc.identifier.rcubConv_2680
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs//bitstream/id/9383/777.pdf
dc.identifier.scopus2-s2.0-80055071240
dc.identifier.wos000296408600009
dc.type.versionpublishedVersion


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