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Predictive modeling of the hypothalamic-pituitary-adrenal (HPA) axis response to acute and chronic stress

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2011
777.pdf (1.367Mb)
Authors
Marković, Vladimir M.
Čupić, Željko
Vukojevic, Vladana
Kolar-Anić, Ljiljana
Article (Published version)
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Abstract
Detailed dynamics of the hypothalamic-pituitary-adrenal (I-IPA) axis is complex, depending on the individual metabolic load of an organism, its current status (healthy/ill, circadian phase (day/night), ultradian phase) and environmental impact. Therefore, it is difficult to compare the HPA axis activity between different individuals or draw unequivocal conclusions about the overall status of the HPA axis in an individual using single time-point measurements of cortisol levels. The aim of this study is to identify parameters that enable us to compare different dynamic states of the HPA axis and use them to investigate self-regulation mechanisms in the HPA axis under acute and chronic stress. In this regard, a four-dimensional stoichiometric model of the HPA axis was used. Acute stress was modeled by inducing an abrupt change in cortisol level during the course of numerical integration, whereas chronic stress was modeled by changing the mean stationary state concentrations of CRH. Effect...s of acute stress intensity, duration and time of onset with respect to the ultradian amplitude, ultradian phase and the circadian phase of the perturbed oscillation were studied in detail. Bifurcation analysis was used to predict the response of the HPA axis to chronic stress. Model predictions were compared with experimental findings reported in the literature and relevance for pharmacotherapy with glucocorticoids was discussed.

Keywords:
HPA axis / Stress / Cortisol / Predictive modeling / Circadian and ultradian rhythmicity
Source:
Endocrine Journal, 2011, 58, 10, 889-904
Publisher:
  • Japan Endocrine Soc, Kyoto
Projects:
  • Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-172015)
  • Nanostructured Functional and Composite Materials in Catalytic and Sorption Processes (RS-45001)
  • Swedish Research Council
  • Swedish Brain Foundation
  • Knut and Alice Wallenberg Foundation

DOI: 10.1507/endocrj.EJ11-0037

ISSN: 0918-8959

PubMed: 21852742

WoS: 000296408600009

Scopus: 2-s2.0-80055071240
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/779
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