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Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide
dc.creator | Eshkourfu, Rabia | |
dc.creator | Čobeljić, Božidar | |
dc.creator | Vujčić, Miroslava | |
dc.creator | Turel, Iztok | |
dc.creator | Pevec, Andrej | |
dc.creator | Sepcic, Kristina | |
dc.creator | Zec, Manja | |
dc.creator | Radulovic, Sinisa | |
dc.creator | Srdic-Radic, Tatjana | |
dc.creator | Mitić, Dragana | |
dc.creator | Anđelković, Katarina | |
dc.creator | Sladić, Dušan | |
dc.date.accessioned | 2019-01-30T17:25:19Z | |
dc.date.available | 2019-01-30T17:25:19Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0162-0134 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/769 | |
dc.description.abstract | A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding. | en |
dc.publisher | Elsevier Science Inc, New York | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.relation | Slovenian Research Agency (ARRS) [P1-0175] | |
dc.rights | restrictedAccess | |
dc.source | Journal of Inorganic Biochemistry | |
dc.subject | Dinuclear cobalt(III) complex | en |
dc.subject | Crystal structure | en |
dc.subject | Apoptosis | en |
dc.subject | DNA binding | en |
dc.title | Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Митиц, Драгана; Сепциц, Кристина; Сладиц, Дуан; Aнђелковиц, Катарина; Срдиц-Радиц, Татјана; Певец, Aндреј; Есхкоурфу, Рабиа; Радуловиц, Синиса; Зец, Мања; Цобељиц, Бзидар; Вујчић, Мирослава; Турел, Изток; | |
dc.citation.volume | 105 | |
dc.citation.issue | 9 | |
dc.citation.spage | 1196 | |
dc.citation.epage | 1203 | |
dc.citation.other | 105(9): 1196-1203 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 21722616 | |
dc.identifier.doi | 10.1016/j.jinorgbio.2011.05.024 | |
dc.identifier.scopus | 2-s2.0-79959678170 | |
dc.identifier.wos | 000294085500011 | |
dc.type.version | publishedVersion |