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dc.creatorEshkourfu, Rabia
dc.creatorČobeljić, Božidar
dc.creatorVujčić, Miroslava
dc.creatorTurel, Iztok
dc.creatorPevec, Andrej
dc.creatorSepcic, Kristina
dc.creatorZec, Manja
dc.creatorRadulovic, Sinisa
dc.creatorSrdic-Radic, Tatjana
dc.creatorMitić, Dragana
dc.creatorAnđelković, Katarina
dc.creatorSladić, Dušan
dc.date.accessioned2019-01-30T17:25:19Z
dc.date.available2019-01-30T17:25:19Z
dc.date.issued2011
dc.identifier.issn0162-0134
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/769
dc.description.abstractA novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationSlovenian Research Agency (ARRS) [P1-0175]
dc.rightsrestrictedAccess
dc.sourceJournal of Inorganic Biochemistry
dc.subjectDinuclear cobalt(III) complexen
dc.subjectCrystal structureen
dc.subjectApoptosisen
dc.subjectDNA bindingen
dc.titleSynthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazideen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМитиц, Драгана; Сепциц, Кристина; Сладиц, Дуан; Aнђелковиц, Катарина; Срдиц-Радиц, Татјана; Певец, Aндреј; Есхкоурфу, Рабиа; Радуловиц, Синиса; Зец, Мања; Цобељиц, Бзидар; Вујчић, Мирослава; Турел, Изток;
dc.citation.volume105
dc.citation.issue9
dc.citation.spage1196
dc.citation.epage1203
dc.citation.other105(9): 1196-1203
dc.citation.rankM21
dc.identifier.pmid21722616
dc.identifier.doi10.1016/j.jinorgbio.2011.05.024
dc.identifier.rcubConv_2649
dc.identifier.scopus2-s2.0-79959678170
dc.identifier.wos000294085500011
dc.type.versionpublishedVersion


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