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Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide

Authorized Users Only
2011
Authors
Eshkourfu, Rabia
Čobeljić, Božidar
Vujčić, Miroslava
Turel, Iztok
Pevec, Andrej
Sepcic, Kristina
Zec, Manja
Radulovic, Sinisa
Srdic-Radic, Tatjana
Mitić, Dragana
Anđelković, Katarina
Sladić, Dušan
Article (Published version)
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Abstract
A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding.
Keywords:
Dinuclear cobalt(III) complex / Crystal structure / Apoptosis / DNA binding
Source:
Journal of Inorganic Biochemistry, 2011, 105, 9, 1196-1203
Publisher:
  • Elsevier Science Inc, New York
Funding / projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
  • Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
  • Slovenian Research Agency (ARRS) [P1-0175]

DOI: 10.1016/j.jinorgbio.2011.05.024

ISSN: 0162-0134

PubMed: 21722616

WoS: 000294085500011

Scopus: 2-s2.0-79959678170
[ Google Scholar ]
88
81
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/769
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Eshkourfu, Rabia
AU  - Čobeljić, Božidar
AU  - Vujčić, Miroslava
AU  - Turel, Iztok
AU  - Pevec, Andrej
AU  - Sepcic, Kristina
AU  - Zec, Manja
AU  - Radulovic, Sinisa
AU  - Srdic-Radic, Tatjana
AU  - Mitić, Dragana
AU  - Anđelković, Katarina
AU  - Sladić, Dušan
PY  - 2011
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/769
AB  - A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide
VL  - 105
IS  - 9
SP  - 1196
EP  - 1203
DO  - 10.1016/j.jinorgbio.2011.05.024
ER  - 
@article{
author = "Eshkourfu, Rabia and Čobeljić, Božidar and Vujčić, Miroslava and Turel, Iztok and Pevec, Andrej and Sepcic, Kristina and Zec, Manja and Radulovic, Sinisa and Srdic-Radic, Tatjana and Mitić, Dragana and Anđelković, Katarina and Sladić, Dušan",
year = "2011",
abstract = "A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide",
volume = "105",
number = "9",
pages = "1196-1203",
doi = "10.1016/j.jinorgbio.2011.05.024"
}
Eshkourfu, R., Čobeljić, B., Vujčić, M., Turel, I., Pevec, A., Sepcic, K., Zec, M., Radulovic, S., Srdic-Radic, T., Mitić, D., Anđelković, K.,& Sladić, D.. (2011). Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 105(9), 1196-1203.
https://doi.org/10.1016/j.jinorgbio.2011.05.024
Eshkourfu R, Čobeljić B, Vujčić M, Turel I, Pevec A, Sepcic K, Zec M, Radulovic S, Srdic-Radic T, Mitić D, Anđelković K, Sladić D. Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry. 2011;105(9):1196-1203.
doi:10.1016/j.jinorgbio.2011.05.024 .
Eshkourfu, Rabia, Čobeljić, Božidar, Vujčić, Miroslava, Turel, Iztok, Pevec, Andrej, Sepcic, Kristina, Zec, Manja, Radulovic, Sinisa, Srdic-Radic, Tatjana, Mitić, Dragana, Anđelković, Katarina, Sladić, Dušan, "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide" in Journal of Inorganic Biochemistry, 105, no. 9 (2011):1196-1203,
https://doi.org/10.1016/j.jinorgbio.2011.05.024 . .

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