Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide
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2011
Authors
Eshkourfu, RabiaČobeljić, Božidar

Vujčić, Miroslava

Turel, Iztok

Pevec, Andrej

Sepcic, Kristina

Zec, Manja

Radulovic, Sinisa
Srdic-Radic, Tatjana
Mitić, Dragana

Anđelković, Katarina

Sladić, Dušan

Article (Published version)

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A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding.
Keywords:
Dinuclear cobalt(III) complex / Crystal structure / Apoptosis / DNA bindingSource:
Journal of Inorganic Biochemistry, 2011, 105, 9, 1196-1203Publisher:
- Elsevier Science Inc, New York
Funding / projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
- Slovenian Research Agency (ARRS) [P1-0175]
DOI: 10.1016/j.jinorgbio.2011.05.024
ISSN: 0162-0134
PubMed: 21722616
WoS: 000294085500011
Scopus: 2-s2.0-79959678170
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IHTMTY - JOUR AU - Eshkourfu, Rabia AU - Čobeljić, Božidar AU - Vujčić, Miroslava AU - Turel, Iztok AU - Pevec, Andrej AU - Sepcic, Kristina AU - Zec, Manja AU - Radulovic, Sinisa AU - Srdic-Radic, Tatjana AU - Mitić, Dragana AU - Anđelković, Katarina AU - Sladić, Dušan PY - 2011 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/769 AB - A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding. PB - Elsevier Science Inc, New York T2 - Journal of Inorganic Biochemistry T1 - Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide VL - 105 IS - 9 SP - 1196 EP - 1203 DO - 10.1016/j.jinorgbio.2011.05.024 ER -
@article{ author = "Eshkourfu, Rabia and Čobeljić, Božidar and Vujčić, Miroslava and Turel, Iztok and Pevec, Andrej and Sepcic, Kristina and Zec, Manja and Radulovic, Sinisa and Srdic-Radic, Tatjana and Mitić, Dragana and Anđelković, Katarina and Sladić, Dušan", year = "2011", abstract = "A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K(b) = 4.2 x 10(5) M(-1)) together with structural analysis of the complex indicate the groove binding.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Inorganic Biochemistry", title = "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide", volume = "105", number = "9", pages = "1196-1203", doi = "10.1016/j.jinorgbio.2011.05.024" }
Eshkourfu, R., Čobeljić, B., Vujčić, M., Turel, I., Pevec, A., Sepcic, K., Zec, M., Radulovic, S., Srdic-Radic, T., Mitić, D., Anđelković, K.,& Sladić, D.. (2011). Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry Elsevier Science Inc, New York., 105(9), 1196-1203. https://doi.org/10.1016/j.jinorgbio.2011.05.024
Eshkourfu R, Čobeljić B, Vujčić M, Turel I, Pevec A, Sepcic K, Zec M, Radulovic S, Srdic-Radic T, Mitić D, Anđelković K, Sladić D. Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry. 2011;105(9):1196-1203. doi:10.1016/j.jinorgbio.2011.05.024 .
Eshkourfu, Rabia, Čobeljić, Božidar, Vujčić, Miroslava, Turel, Iztok, Pevec, Andrej, Sepcic, Kristina, Zec, Manja, Radulovic, Sinisa, Srdic-Radic, Tatjana, Mitić, Dragana, Anđelković, Katarina, Sladić, Dušan, "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide" in Journal of Inorganic Biochemistry, 105, no. 9 (2011):1196-1203, https://doi.org/10.1016/j.jinorgbio.2011.05.024 . .