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Peroxisome Proliferator-Activated Receptors and Atherosclerosis

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2011
Authors
Soskic, Sanja S.
Dobutovic, Branislava D.
Sudar, Emina M.
Obradovic, Milan M.
Nikolic, Dragana M.
Zarić, Božidarka
Stojanović, Srđan
Stokic, Edita J.
Mikhailidis, Dimitri P.
Isenovic, Esma R.
Article (Published version)
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Abstract
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents... in the treatment of complex disease such as atherosclerosis.

Keywords:
peroxisome proliferator-activated receptors alpha / atherosclerosis / peroxisome proliferator-activated receptors gamma / atherosclerotic plaque
Source:
Angiology, 2011, 62, 7, 523-534
Publisher:
  • Sage Publications Inc, Thousand Oaks
Projects:
  • Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-173033)
  • The study of physicochemical and biochemical processes in living environment that have impacts on pollution and the investigation of possibilities for minimizing the consequences (RS-172001)

DOI: 10.1177/0003319711401012

ISSN: 0003-3197

PubMed: 21467121

WoS: 000295729400003

Scopus: 2-s2.0-80054761005
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/762
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IHTM

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