Peroxisome Proliferator-Activated Receptors and Atherosclerosis
Authorized Users Only
2011
Authors
Soskic, Sanja S.
Dobutovic, Branislava D.
Sudar, Emina M.

Obradovic, Milan M.

Nikolic, Dragana M.

Zarić, Božidarka

Stojanović, Srđan

Stokic, Edita J.
Mikhailidis, Dimitri P.
Isenovic, Esma R.

Article (Published version)

Metadata
Show full item recordAbstract
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents... in the treatment of complex disease such as atherosclerosis.
Keywords:
peroxisome proliferator-activated receptors alpha / atherosclerosis / peroxisome proliferator-activated receptors gamma / atherosclerotic plaqueSource:
Angiology, 2011, 62, 7, 523-534Publisher:
- Sage Publications Inc, Thousand Oaks
Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-173033)
- The study of physicochemical and biochemical processes in living environment that have impacts on pollution and the investigation of possibilities for minimizing the consequences (RS-172001)
DOI: 10.1177/0003319711401012
ISSN: 0003-3197
PubMed: 21467121
WoS: 000295729400003
Scopus: 2-s2.0-80054761005
Collections
Institution/Community
IHTMTY - JOUR AU - Soskic, Sanja S. AU - Dobutovic, Branislava D. AU - Sudar, Emina M. AU - Obradovic, Milan M. AU - Nikolic, Dragana M. AU - Zarić, Božidarka AU - Stojanović, Srđan AU - Stokic, Edita J. AU - Mikhailidis, Dimitri P. AU - Isenovic, Esma R. PY - 2011 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/762 AB - The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. PB - Sage Publications Inc, Thousand Oaks T2 - Angiology T1 - Peroxisome Proliferator-Activated Receptors and Atherosclerosis VL - 62 IS - 7 SP - 523 EP - 534 DO - 10.1177/0003319711401012 ER -
@article{ author = "Soskic, Sanja S. and Dobutovic, Branislava D. and Sudar, Emina M. and Obradovic, Milan M. and Nikolic, Dragana M. and Zarić, Božidarka and Stojanović, Srđan and Stokic, Edita J. and Mikhailidis, Dimitri P. and Isenovic, Esma R.", year = "2011", abstract = "The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Angiology", title = "Peroxisome Proliferator-Activated Receptors and Atherosclerosis", volume = "62", number = "7", pages = "523-534", doi = "10.1177/0003319711401012" }
Soskic, S. S., Dobutovic, B. D., Sudar, E. M., Obradovic, M. M., Nikolic, D. M., Zarić, B., Stojanović, S., Stokic, E. J., Mikhailidis, D. P.,& Isenovic, E. R.. (2011). Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology Sage Publications Inc, Thousand Oaks., 62(7), 523-534. https://doi.org/10.1177/0003319711401012
Soskic SS, Dobutovic BD, Sudar EM, Obradovic MM, Nikolic DM, Zarić B, Stojanović S, Stokic EJ, Mikhailidis DP, Isenovic ER. Peroxisome Proliferator-Activated Receptors and Atherosclerosis. in Angiology. 2011;62(7):523-534. doi:10.1177/0003319711401012 .
Soskic, Sanja S., Dobutovic, Branislava D., Sudar, Emina M., Obradovic, Milan M., Nikolic, Dragana M., Zarić, Božidarka, Stojanović, Srđan, Stokic, Edita J., Mikhailidis, Dimitri P., Isenovic, Esma R., "Peroxisome Proliferator-Activated Receptors and Atherosclerosis" in Angiology, 62, no. 7 (2011):523-534, https://doi.org/10.1177/0003319711401012 . .