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Ribofuranoza kao nosač tetraoksanske i 4-aminohinolinske antimalarijske farmakofore

dc.creatorOpsenica, Igor
dc.creatorSmith, Kirsten K.
dc.creatorGerena, Lucia
dc.creatorGaica, Sandra
dc.creatorŠolaja, Bogdan
dc.date.accessioned2024-03-26T14:40:26Z
dc.date.available2024-03-26T14:40:26Z
dc.date.issued2008
dc.identifier.issn0352-5139
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/7535
dc.description.abstractSeveral tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ).sr
dc.description.abstractU ovom radu prikazana je sinteza nekoliko ribofuranozidnih tetraoksana i 4-aminohinolina u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja su pokazala izraženu antimalarijsku aktivnost prema hlorokin-osetljivom (D6), hlorokin-rezistentnom (W2) i višestruko rezistentnom (TM91C235 (Thailand)) soju Plasmodium falciparum. Aminohinolinski derivat 4 je aktivniji prema W2 i TM91C235 sojevima od kontrolnih jedinjenja (hlorokin i meflokin).sr
dc.language.isoensr
dc.publisherBelgrade : Serbian Chemical Societysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//sr
dc.relationSerbian Academy of Sciences and Artssr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Serbian Chemical Societysr
dc.subjectTetraoxanessr
dc.subject4-aminoquinolinessr
dc.subjectmalariasr
dc.subjectP. falciparum.sr
dc.titleRibofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophoressr
dc.titleRibofuranoza kao nosač tetraoksanske i 4-aminohinolinske antimalarijske farmakoforesr
dc.typearticlesr
dc.rights.licenseBY-NC-NDsr
dc.citation.volume73
dc.citation.issue11
dc.citation.spage1021
dc.citation.epage1025
dc.citation.rankM23
dc.identifier.doi10.2298/JSC0811021О
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/29970/4.3..pdf
dc.identifier.scopus2-s2.0-55549130272
dc.identifier.wos000261070600001
dc.type.versionpublishedVersionsr


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