Supplementary material to: "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity"
Аутори
Vitomirov, TeodoraČobeljić, Božidar
Pevec, Andrej
Radanović, Dušanka
Novaković, Irena
Savić, Milica
Anđelković, Katarina
Šumar-Ristović, Maja
Скуп података (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The condensation product of 7-acetyl-6-azaindole and Girard's T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)-N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2·6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3-N3) azide bridge binding mode has not yet occurred in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P–1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3−) ligand, and BF...4− counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B.
Кључне речи:
Girard's T reagent / X-ray crystallography / antibacterial activity / antifungal activity / dinuclear complexes / azide bridges / Cu(II)Извор:
2023Издавач:
- Serbian Chemical Society
Финансирање / пројекти:
- TMMagCat - Tailoring Molecular Magnets and Catalysts Based on Transition Metal Complexes (RS-ScienceFundRS-Ideje-7750288)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Slovenian Research Agency (ARRS), grant number P1-0175
Напомена:
- Accepted version of the manuscript: https://cer.ihtm.bg.ac.rs/handle/123456789/6435
- Published version of the manuscript: https://cer.ihtm.bg.ac.rs/handle/123456789/7320
- Supplementary material for: Vitomirov, Teodora, Čobeljić, Božidar, Pevec, Andrej, Radanović, Dušanka, Novaković, Irena, Savić, Milica, Anđelković, Katarina, Šumar-Ristović, Maja, "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity" in Journal of the Serbian Chemical Society, 88, no. 9 (2023):877-888, https://doi.org/10.2298/JSC230623044V
Повезане информације:
- Повезани садржај
https://cer.ihtm.bg.ac.rs/handle/123456789/7320 - Повезани садржај
https://cer.ihtm.bg.ac.rs/handle/123456789/6435 - Повезани садржај
https://doi.org/10.2298/JSC230623044V
Колекције
Институција/група
IHTMTY - DATA AU - Vitomirov, Teodora AU - Čobeljić, Božidar AU - Pevec, Andrej AU - Radanović, Dušanka AU - Novaković, Irena AU - Savić, Milica AU - Anđelković, Katarina AU - Šumar-Ristović, Maja PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7528 AB - The condensation product of 7-acetyl-6-azaindole and Girard's T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)-N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2·6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3-N3) azide bridge binding mode has not yet occurred in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P–1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3−) ligand, and BF4− counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B. PB - Serbian Chemical Society T1 - Supplementary material to: "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity" UR - https://hdl.handle.net/21.15107/rcub_cer_7528 ER -
@misc{ author = "Vitomirov, Teodora and Čobeljić, Božidar and Pevec, Andrej and Radanović, Dušanka and Novaković, Irena and Savić, Milica and Anđelković, Katarina and Šumar-Ristović, Maja", year = "2023", abstract = "The condensation product of 7-acetyl-6-azaindole and Girard's T reagent ((E)-2-(2-(1-(1H-pyrrolo[2,3-c]pyridin-7-yl)ethylidene)hydrazineyl)-N,N,N-trimethyl-2-oxoethan-1-aminium, HL ligand) was used as a ligand in the reaction with Cu(BF4)2·6H2O and NaN3. The reaction led to the formation of a binuclear Cu(II) complex containing two end-to-end (di-m-1,3-N3) azide bridges, as well as two NNO-donor hydrazone ligands, forming an axially elongated square pyramidal geometry around each Cu(II) center. This end-to-end (di-m-1,3-N3) azide bridge binding mode has not yet occurred in Cu(II) complexes containing the NNO-donor hydrazone ligands, which makes the structure of the complex even more interesting for further studies. The complex was characterized by elemental analysis, IR spectroscopy and X-ray crystallography, and it was found that it crystallizes in the triclinic space group P–1 with the asymmetric unit comprising one Cu(II) centre, zwitterionic ligand L, one azide (N3−) ligand, and BF4− counter anion. Examination of antimicrobial activity of the complex shows higher antifungal and antibacterial activity towards tested Gram-positive bacteria in comparison to the hydrazone ligand, with the antifungal activity of the complex even being comparable to the activity of amphotericin B.", publisher = "Serbian Chemical Society", title = "Supplementary material to: "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity"", url = "https://hdl.handle.net/21.15107/rcub_cer_7528" }
Vitomirov, T., Čobeljić, B., Pevec, A., Radanović, D., Novaković, I., Savić, M., Anđelković, K.,& Šumar-Ristović, M.. (2023). Supplementary material to: "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity". Serbian Chemical Society.. https://hdl.handle.net/21.15107/rcub_cer_7528
Vitomirov T, Čobeljić B, Pevec A, Radanović D, Novaković I, Savić M, Anđelković K, Šumar-Ristović M. Supplementary material to: "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity". 2023;. https://hdl.handle.net/21.15107/rcub_cer_7528 .
Vitomirov, Teodora, Čobeljić, Božidar, Pevec, Andrej, Radanović, Dušanka, Novaković, Irena, Savić, Milica, Anđelković, Katarina, Šumar-Ristović, Maja, "Supplementary material to: "Binuclear azide-bridged hydrazone Cu(II) complex: Synthesis, characterization and evaluation of biological activity"" (2023), https://hdl.handle.net/21.15107/rcub_cer_7528 .