Biobased poly(methacrylic acid) hydrogels: swelling properties and contorlled release of caffeine

Abstract

Modern society are faced with lot of challenges in the treatment of many diseases, especiallywith serious ones such as cancer. Safer and more efficient treatment of the cancer patients are maingoals which researchers are aiming. One of the good approaches can be drug delivery systems.Still, a lot of anticancer drugs are poorly water-soluble and their encapsulation and controlled releasecan be quite challenging. Present study is focused to improve drug delivery system based onhydrophilic poly(methacrylic acid) and amphiphilic casein with encapsulated poorly water-solublecaffeine, which has been developed through our previous research. The hydrogels with 1.6mol% ofcrosslinker and 100% of neutralization degree of methacrylic acid are synthetized (PMAC-100N-4M). The swelling process of the PMAC-100N-4M hydrogels and caffeine release are analyzed intwo environments which simulate human stomach and intestines. It is also investigated how thechange in the encapsulated caffeine weight and the addition of liposomes with encapsulated caffeine,affect swelling degree of the PMAC-100N-4M hydrogels and release of caffeine. The resultsshow that controlled release of caffeine is improved, therefore overall therapy can be enhanced.

Savremeno društvo je suočeno sa mnogim izazovima u tretamanu raznih bolesti, naročito ozbiljnih oboljenja kao što je rak. Glavni ciljevi naučnika su da se postigne bezbednija i efikasnija terapija pacijenata koji se leče od raka. Jedan od dobrih načina da se to postigne su sistemi za dostavu lekova. Ipak, mnogi antikancerogeni lekovi su slabovodorastvorni, pa bi veliki izazov mogao da bude inakpsulacija i njihovo kontorlisano otpuštanje iz sistema za dostavu lekova. Cilj ovog rada je da se unapredi sistem za dostavu lekova na bazi hidrofilne poli(metakrilne kiseline) i amfifilnog kazeina sa inkapsuliarnim slabo vodorastvornim kofeinom, koji je razvijen tokom našeg prethodnog istraživanja. U ovom radu sintetisani su hidrogelovi sa 1,6mol% umreživača i 100% neutralisanom metakrilnom kiselinom (PMAC-100N-4M). Procesi bubrenja PMAC-100N-4M hidrogelova i kontrolisanog otpuštanja kofeina su ispitivani u dve sredine koje simuliraju želudac i tanko crevo čoveka. Takođe je ispitano kako promena količine inkapsuliranog kofeina i dodatak lipozomne suspenzije sa inkapsuliranim kofeinom utiče na procese bubrenja PMAC-100N-4M hidorgelova i otpuštanje kofeina. Rezultati pokazuju da je proces kontrolisanog otpuštanje kofeina unapređen, a samim tim je moguće unaprediti i celokupnu terapiju.