Приказ основних података о документу
The Stability of Wild Thyme Extract-Loaded Phospholipid-Cholesterol Liposomal Particles
Stabilnost lipozomalnih čestica sa inkapsuliranim ekstraktom majčine dušice
dc.creator | Jovanović, Aleksandra A. | |
dc.creator | Rajab Elferjane, Muna | |
dc.creator | Milošević, Milena | |
dc.creator | Batinić, Petar | |
dc.creator | Bošnjaković, Jovana | |
dc.creator | Rančić, Milica | |
dc.creator | Marinković, Aleksandar | |
dc.date.accessioned | 2024-01-15T12:16:10Z | |
dc.date.available | 2024-01-15T12:16:10Z | |
dc.date.issued | 2023 | |
dc.identifier.isbn | 978-86-82343-30-1 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/7333 | |
dc.description.abstract | Wild thyme contains biologically active compounds, particularly polyphenols (flavonoids and phenolic acids) that exert antitumor, antimicrobial, anti-inflammatory, antioxidant, immunomodulatory, analgesic, and spasmolytic activities. Nevertheless, the mentioned bioactive compounds have low stability, solubility, and bioavailability, thus their application is limited. Liposomal particles have been widely used for the encapsulation of bioactive components, due to their high structural integrity, stability during storage, and controlled release capability. In the present study, phospholipid-cholesterol liposomal particles, as the carrier for wild thyme extract, were developed. The stability of extract-loaded liposomes was monitored for 21 days by measuring vesicle size, polydispersity index (PDI), and zeta potential. The particle size and PDI of extract-loaded liposomes did not change drastically during 21 days of storage and amounted to ~450 nm and ~0.155, respectively. The zeta potential varied in the liposomes and started to decrease after 7 days of storage (from -21.0 mV to 20.3 mV, without a statistically significant difference), while the zeta potential value after 21 days was statistically significantly lower in comparison to the 1st day (19.3 mV). The beneficial effects of polyphenols on human health, as well as showed storage stability of the prepared liposomes highlight the use of the wild thyme extract-loaded phospholipid-cholesterol liposomal particles for potential application in food, pharmaceutical, and cosmetic industries. | sr |
dc.language.iso | en | sr |
dc.publisher | Serbian society of corrosion and materials protection (UISKoZaM) / Udruženje inženjera Srbije za koroziju i zaštitu materijala | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200026/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200003/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200019/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200066/RS// | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200169/RS// | sr |
dc.rights | openAccess | sr |
dc.source | Proceedings - XXIV YuCorr International Conference, Meeting Point of the Science and Practice in the Fields of Corrosion, Materials and Environmental Protection, May 28-31, 2023, Divčibare, Serbia | sr |
dc.subject | liposomal particles | sr |
dc.subject | phospholipids | sr |
dc.subject | stability | sr |
dc.subject | wild thyme | sr |
dc.title | The Stability of Wild Thyme Extract-Loaded Phospholipid-Cholesterol Liposomal Particles | sr |
dc.title | Stabilnost lipozomalnih čestica sa inkapsuliranim ekstraktom majčine dušice | sr |
dc.type | conferenceObject | sr |
dc.rights.license | ARR | sr |
dc.citation.spage | 96 | |
dc.citation.epage | 101 | |
dc.citation.rank | M33 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cer_7333 | |
dc.identifier.fulltext | http://cer.ihtm.bg.ac.rs/bitstream/id/29360/The_Stability_of_Wild_Thyme.pdf | |
dc.type.version | publishedVersion | sr |