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dc.creatorBožić, Tatjana T.
dc.creatorNovaković, Irena
dc.creatorGašić, Miroslav J.
dc.creatorJuranić, Zorica
dc.creatorStanojković, Tatjana
dc.creatorTufegdžić, Srđan
dc.creatorKljajić, Zoran
dc.creatorSladić, Dušan
dc.date.accessioned2019-01-30T17:24:30Z
dc.date.available2019-01-30T17:24:30Z
dc.date.issued2010
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/730
dc.description.abstractNine alkyl(aryl)thio derivatives of the marine sesquiterpene quinone avarone were synthesized by nucleophilic addition of thiols or thiophenol to avarone. In most cases only one regioisomer was obtained. Their cytotoxic activities, brine shrimp lethality and antibacterial activity were evaluated, as well as those of some previously synthesized avarone derivatives. Anti-HIV activity of two derivatives was tested. Electrochemical properties were determined for all the derivatives in Order to obtain more accurate information on structure-activity relationships. Most derivatives showed cytotoxic activity against tumor cell lines, with IC50 values less than 10 mu M for some of them, in particular those with electron-donating substituents. The most active Compound was 4'-(methylamino)avarone, with IC50 value of 2.4 mu M to melanoma Fem-X cells, and no cytotoxicity to normal lymphocytes.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142026/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectMarine quinoneen
dc.subjectAvaroneen
dc.subjectAlkyl(aryl)thio derivativesen
dc.subjectcytotoxic activityen
dc.subjectCyclic voltammetryen
dc.titleSynthesis and biological activity of derivatives of the marine quinone avaroneen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСладиц, Дусан; Кљајиц, Зоран; Јураниц, Зорица; Туфегджић, Срђан; Станојковиц, Татјана; Бозиц, Татјана; Новаковић, Ирена; Гасиц, Мирослав Ј.;
dc.citation.volume45
dc.citation.issue3
dc.citation.spage923
dc.citation.epage929
dc.citation.other45(3): 923-929
dc.citation.rankM21
dc.identifier.pmid19995673
dc.identifier.doi10.1016/j.ejmech.2009.11.033
dc.identifier.rcubConv_2331
dc.identifier.scopus2-s2.0-75949110978
dc.identifier.wos000275404900010
dc.type.versionpublishedVersion


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