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dc.creatorVujic, Jelena M.
dc.creatorCvijovic, Milica
dc.creatorKaluđerović, Goran N.
dc.creatorMilovanovic, Marija
dc.creatorZmejkovski, Bojana
dc.creatorVolarevic, Vladislav
dc.creatorArsenijevic, Nebojsa
dc.creatorSabo, Tibor
dc.creatorTrifunovic, Srecko R.
dc.date.accessioned2019-01-30T17:24:05Z
dc.date.available2019-01-30T17:24:05Z
dc.date.issued2010
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/710
dc.description.abstractFour novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 center dot 2HCl-L4 center dot 2HCl, of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride [(S,S)-H(4)eddl]Cl-2 and the corresponding palladium(II) complexes 1-4, were prepared and characterized by IR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. In vitro cytotoxicity of all compounds was determined against chronic lymphocytic leukemia cells (CLL). The compounds were found to exhibit higher antitumoral activity than cisplatin. The most active compound 2, [PdCl2{(S,S)-nPr(2)eddl}], was found to be 13.6 times more active than cisplatin on CLL cells.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142008/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145065/RS//
dc.relationEC
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectPalladium(II) complexesen
dc.subjectEdda-type ligandsen
dc.subjectAntitumoral activityen
dc.subjectChronic lymphocytic leukemia cellsen
dc.titlePalladium(II) complexes with R(2)edda derived ligands. Part IV. O,O '-dialkyl esters of (S,S)-ethylenediamine-N,N '-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral actien
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТрифуновиц, Срецко Р.; Вујиц, Јелена М.; Цвијовиц, Милица; Миловановиц, Марија; Aрсенијевиц, Небојса; Воларевиц, Владислав; Змејковски, Бојана; Сабо, Тибор Ј.; Калудеровиц, Горан Н.;
dc.citation.volume45
dc.citation.issue9
dc.citation.spage3601
dc.citation.epage3606
dc.citation.other45(9): 3601-3606
dc.citation.rankM21
dc.identifier.pmid20570025
dc.identifier.doi10.1016/j.ejmech.2010.05.005
dc.identifier.rcubConv_2548
dc.identifier.scopus2-s2.0-77955558644
dc.identifier.wos000281568600011
dc.type.versionpublishedVersion


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