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Bromophilic substitution/carbophilic substitution cascade reactions of alpha,alpha-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles

Authorized Users Only
2010
Authors
Tatar, Jovana
Marković, Rade
Stojanović, Milovan
Baranac-Stojanović, Marija
Article (Published version)
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Abstract
alpha,alpha-Dibromo-2-methoxyacetophenone reacts, under mild reaction conditions, with C-, N- and O-nucleophiles via a bromophilic substitution/protonation/carbophilic substitution cascade process to afford alpha-monosubstituted-2-methoxyacetophenones in moderate to good yield. The only exception from this reaction pathway is the reaction with the anion derived from malononitrile in which 2-aroyl-1,1,3,3-tetracyanopropene is obtained.
Keywords:
alpha,alpha-Dibromomethylketone / Bromophilic reaction / Nucleophilic substitution / Cascade reactions
Source:
Tetrahedron Letters, 2010, 51, 37, 4851-4855
Publisher:
  • Oxford : Pergamon-Elsevier Science Ltd
Funding / projects:
  • Tiazolidni i sintetički analozi: reaktivnost, primena i biološka aktivnost (RS-142007)

DOI: 10.1016/j.tetlet.2010.07.057

ISSN: 0040-4039

WoS: 000281356700017

Scopus: 2-s2.0-77955848118
[ Google Scholar ]
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URI
https://cer.ihtm.bg.ac.rs/handle/123456789/703
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Tatar, Jovana
AU  - Marković, Rade
AU  - Stojanović, Milovan
AU  - Baranac-Stojanović, Marija
PY  - 2010
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/703
AB  - alpha,alpha-Dibromo-2-methoxyacetophenone reacts, under mild reaction conditions, with C-, N- and O-nucleophiles via a bromophilic substitution/protonation/carbophilic substitution cascade process to afford alpha-monosubstituted-2-methoxyacetophenones in moderate to good yield. The only exception from this reaction pathway is the reaction with the anion derived from malononitrile in which 2-aroyl-1,1,3,3-tetracyanopropene is obtained.
PB  - Oxford : Pergamon-Elsevier Science Ltd
T2  - Tetrahedron Letters
T1  - Bromophilic substitution/carbophilic substitution cascade reactions of alpha,alpha-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles
VL  - 51
IS  - 37
SP  - 4851
EP  - 4855
DO  - 10.1016/j.tetlet.2010.07.057
ER  - 
@article{
author = "Tatar, Jovana and Marković, Rade and Stojanović, Milovan and Baranac-Stojanović, Marija",
year = "2010",
abstract = "alpha,alpha-Dibromo-2-methoxyacetophenone reacts, under mild reaction conditions, with C-, N- and O-nucleophiles via a bromophilic substitution/protonation/carbophilic substitution cascade process to afford alpha-monosubstituted-2-methoxyacetophenones in moderate to good yield. The only exception from this reaction pathway is the reaction with the anion derived from malononitrile in which 2-aroyl-1,1,3,3-tetracyanopropene is obtained.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Tetrahedron Letters",
title = "Bromophilic substitution/carbophilic substitution cascade reactions of alpha,alpha-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles",
volume = "51",
number = "37",
pages = "4851-4855",
doi = "10.1016/j.tetlet.2010.07.057"
}
Tatar, J., Marković, R., Stojanović, M.,& Baranac-Stojanović, M.. (2010). Bromophilic substitution/carbophilic substitution cascade reactions of alpha,alpha-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles. in Tetrahedron Letters
Oxford : Pergamon-Elsevier Science Ltd., 51(37), 4851-4855.
https://doi.org/10.1016/j.tetlet.2010.07.057
Tatar J, Marković R, Stojanović M, Baranac-Stojanović M. Bromophilic substitution/carbophilic substitution cascade reactions of alpha,alpha-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles. in Tetrahedron Letters. 2010;51(37):4851-4855.
doi:10.1016/j.tetlet.2010.07.057 .
Tatar, Jovana, Marković, Rade, Stojanović, Milovan, Baranac-Stojanović, Marija, "Bromophilic substitution/carbophilic substitution cascade reactions of alpha,alpha-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles" in Tetrahedron Letters, 51, no. 37 (2010):4851-4855,
https://doi.org/10.1016/j.tetlet.2010.07.057 . .

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