Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts
Authors
Zdunić, GordanaGođevac, Dejan
Milenković, Marina
Savikin, Katarina
Menković, Nebojša
Petrovic, Silvana
Article (Published version)
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Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.
Keywords:
Hypericum richeri Vill. / oil extracts / quercetin / I3,II8-biapigenin / anti-inflammatory activity / gastroprotective activitySource:
Natural Product Communications, 2010, 5, 8, 1215-1218Publisher:
- Natural Product Incorporation
Funding / projects:
- Biljni proizvodi u preventivi i terapiji nezaraznih hroničnih oboljenja kod ljudi (RS-20035)
- Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija (RS-143012)
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IHTMTY - JOUR AU - Zdunić, Gordana AU - Gođevac, Dejan AU - Milenković, Marina AU - Savikin, Katarina AU - Menković, Nebojša AU - Petrovic, Silvana PY - 2010 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/702 AB - Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent. PB - Natural Product Incorporation T2 - Natural Product Communications T1 - Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts VL - 5 IS - 8 SP - 1215 EP - 1218 UR - https://hdl.handle.net/21.15107/rcub_cer_702 ER -
@article{ author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Savikin, Katarina and Menković, Nebojša and Petrovic, Silvana", year = "2010", abstract = "Oil extracts of flowering tops of Hypericum richeri Vill. prepared in three different ways were evaluated for chemical composition, and anti-inflammatory and gastroprotective activities. An HPLC method was developed for determination of two dominant flavonoids, quercetin and I3,II8-biapigenin. The carrageenan-induced rat paw edema test was used for screening the anti-inflammatory activity, while indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. The oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath, exhibited the highest anti-inflammatory (38.4 %) and gastroprotective activities (gastric damage score of 0.9). The same oil extract had the highest content of quercetin (49 mu g/mL) and I3,II8-biapigenin (60 mu g/mL). These results approve the usage of oil extracts of H. richeri as an anti-inflammatory and gastroprotective agent.", publisher = "Natural Product Incorporation", journal = "Natural Product Communications", title = "Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts", volume = "5", number = "8", pages = "1215-1218", url = "https://hdl.handle.net/21.15107/rcub_cer_702" }
Zdunić, G., Gođevac, D., Milenković, M., Savikin, K., Menković, N.,& Petrovic, S.. (2010). Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts. in Natural Product Communications Natural Product Incorporation., 5(8), 1215-1218. https://hdl.handle.net/21.15107/rcub_cer_702
Zdunić G, Gođevac D, Milenković M, Savikin K, Menković N, Petrovic S. Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts. in Natural Product Communications. 2010;5(8):1215-1218. https://hdl.handle.net/21.15107/rcub_cer_702 .
Zdunić, Gordana, Gođevac, Dejan, Milenković, Marina, Savikin, Katarina, Menković, Nebojša, Petrovic, Silvana, "Anti-inflammatory and Gastroprotective Properties of Hypericum richeri Oil Extracts" in Natural Product Communications, 5, no. 8 (2010):1215-1218, https://hdl.handle.net/21.15107/rcub_cer_702 .