Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit
2023
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Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Due to the presence of a large number of double bonds, fullerene C60 shows good antioxidant and moderate anti-inflammatory properties. At the same time, natural product vanillin, thanks to its phenolic subunit expresses the same activities, although in a lesser extent. Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and vanillin. The Prato reaction of the glycine derivative, vanillin and the fullerene C60 provided desired products in satisfactory yields. DPPH radical scavenging activity and β-carotene-linoleic acid bleaching assay were used to determine antioxidant activity, while
for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained fulleropyrrolidines showed significantly better biological activity in comparison with starting compound.
Кључне речи:
fullerene / fulleropyrrolidines / synthesis / Prato reaction / DPPH radical scavenging activityИзвор:
9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia, 2023, 74-74Издавач:
- Belgrade : Serbian Chemical Society
- Belgrade : Serbian Young Chemists’ Club
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-MESTD-inst-2020-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
Институција/група
IHTMTY - CONF AU - Kotlaja, Katarina AU - Trifković, Željko AU - Kop, Tatjana AU - Milić, Dragana PY - 2023 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/7014 AB - Due to the presence of a large number of double bonds, fullerene C60 shows good antioxidant and moderate anti-inflammatory properties. At the same time, natural product vanillin, thanks to its phenolic subunit expresses the same activities, although in a lesser extent. Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and vanillin. The Prato reaction of the glycine derivative, vanillin and the fullerene C60 provided desired products in satisfactory yields. DPPH radical scavenging activity and β-carotene-linoleic acid bleaching assay were used to determine antioxidant activity, while for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained fulleropyrrolidines showed significantly better biological activity in comparison with starting compound. PB - Belgrade : Serbian Chemical Society PB - Belgrade : Serbian Young Chemists’ Club C3 - 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia T1 - Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit SP - 74 EP - 74 UR - https://hdl.handle.net/21.15107/rcub_cer_7014 ER -
@conference{ author = "Kotlaja, Katarina and Trifković, Željko and Kop, Tatjana and Milić, Dragana", year = "2023", abstract = "Due to the presence of a large number of double bonds, fullerene C60 shows good antioxidant and moderate anti-inflammatory properties. At the same time, natural product vanillin, thanks to its phenolic subunit expresses the same activities, although in a lesser extent. Willing to obtain novel fulleropyrrolidines with improved biological activity, we explored the synthesis of hybrid structures containing fullerene and vanillin. The Prato reaction of the glycine derivative, vanillin and the fullerene C60 provided desired products in satisfactory yields. DPPH radical scavenging activity and β-carotene-linoleic acid bleaching assay were used to determine antioxidant activity, while for evaluation of anti-inflammatory activity, ovalbumin (OVA) and bovine serum albumin (BSA) thermal denaturation inhibition assays were used. Obtained fulleropyrrolidines showed significantly better biological activity in comparison with starting compound.", publisher = "Belgrade : Serbian Chemical Society, Belgrade : Serbian Young Chemists’ Club", journal = "9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia", title = "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit", pages = "74-74", url = "https://hdl.handle.net/21.15107/rcub_cer_7014" }
Kotlaja, K., Trifković, Ž., Kop, T.,& Milić, D.. (2023). Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia Belgrade : Serbian Chemical Society., 74-74. https://hdl.handle.net/21.15107/rcub_cer_7014
Kotlaja K, Trifković Ž, Kop T, Milić D. Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit. in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia. 2023;:74-74. https://hdl.handle.net/21.15107/rcub_cer_7014 .
Kotlaja, Katarina, Trifković, Željko, Kop, Tatjana, Milić, Dragana, "Synthesis and determination of in vitro biological activity of novel fulleropyrrolidines containing vanilin subunit" in 9th Conference of Young Chemists of Serbia, Book of abstracts, 4th November 2023, Novi Sad, Serbia (2023):74-74, https://hdl.handle.net/21.15107/rcub_cer_7014 .