Synthesis and determination of in vitro antioxidant activities of novel fulleropyrrolidines containing aromatic subunit

Abstract

Due to the presence of a large number of double bonds, fullerene C60 shows good radical scavenging properties. In order to obtain novel fulleropyrrolidine with improved antioxidant activity, we explored the synthesis of a hybrid structure containing fullerene and anisole subunit. The Prato reaction of the N-substituted glycine, aromatic aldehyde with anisole subunits and the fullerene C60 provided desired products in a satisfactory yield. The obtained compound was added to the series of similar fulleropyrrolidines and subjected to an antioxidant activity test using β–carotene-linoleic acid bleaching assay.