Experimental study of antioxidant and anticancer activity of new asymmetrically substituted thiocarbohydrazones
Аутори
Milošević, MilenaCvijetić, Ilija
Božić, Aleksandra
Prlainović, Nevena
Bjelogrlić, Snežana
Popović, Mina
Marinković, Aleksandar
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Thiocarbohydrazones and their derivatives represent a class of compounds with various biological and pharmaceutical properties, including strong antioxidant, antitubercular, antimicrobial, and anticancer activity [1]. Therefore, in this work, new asymmetrically substituted bis-(thiocarbohydrazones) (TCHs) bearing 2-pyridine and quinoline moiety were synthesized and showed promising in vitro antioxidant and anticancer activity (Figure1). The results suggest that antioxidant activity of TCH depends on the structure, substituent type and antioxidant assay used. The maximum antioxidant activity in DPPH and CUPRAC tests was observed for compound with 8-quinolyl and 8-hydroxy-2quinolyl moiety. Additionally, anticancer assays revealed that compounds interfere with cancer cell mobility at concentrations below 10 μM, and exert low toxicity toward healthy human HaCaT fibroblasts. The results of this study represent a good foundation for further research and development of novel iminopyridines wi...th improved antioxidant and anticancer activity.
Кључне речи:
Thiocarbohydrazones / iminopyridines / antioxidants / anticancer activityИзвор:
18th Hellenic Symposium on Medicinal Chemistry, on-line, Greece, 25-27 February 2021, 2021, P065-Издавач:
- Hellenic Society of Medicinal Chemistry (HSMC)
Институција/група
IHTMTY - CONF AU - Milošević, Milena AU - Cvijetić, Ilija AU - Božić, Aleksandra AU - Prlainović, Nevena AU - Bjelogrlić, Snežana AU - Popović, Mina AU - Marinković, Aleksandar PY - 2021 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6963 AB - Thiocarbohydrazones and their derivatives represent a class of compounds with various biological and pharmaceutical properties, including strong antioxidant, antitubercular, antimicrobial, and anticancer activity [1]. Therefore, in this work, new asymmetrically substituted bis-(thiocarbohydrazones) (TCHs) bearing 2-pyridine and quinoline moiety were synthesized and showed promising in vitro antioxidant and anticancer activity (Figure1). The results suggest that antioxidant activity of TCH depends on the structure, substituent type and antioxidant assay used. The maximum antioxidant activity in DPPH and CUPRAC tests was observed for compound with 8-quinolyl and 8-hydroxy-2quinolyl moiety. Additionally, anticancer assays revealed that compounds interfere with cancer cell mobility at concentrations below 10 μM, and exert low toxicity toward healthy human HaCaT fibroblasts. The results of this study represent a good foundation for further research and development of novel iminopyridines with improved antioxidant and anticancer activity. PB - Hellenic Society of Medicinal Chemistry (HSMC) C3 - 18th Hellenic Symposium on Medicinal Chemistry, on-line, Greece, 25-27 February 2021 T1 - Experimental study of antioxidant and anticancer activity of new asymmetrically substituted thiocarbohydrazones SP - P065 UR - https://hdl.handle.net/21.15107/rcub_cer_6963 ER -
@conference{ author = "Milošević, Milena and Cvijetić, Ilija and Božić, Aleksandra and Prlainović, Nevena and Bjelogrlić, Snežana and Popović, Mina and Marinković, Aleksandar", year = "2021", abstract = "Thiocarbohydrazones and their derivatives represent a class of compounds with various biological and pharmaceutical properties, including strong antioxidant, antitubercular, antimicrobial, and anticancer activity [1]. Therefore, in this work, new asymmetrically substituted bis-(thiocarbohydrazones) (TCHs) bearing 2-pyridine and quinoline moiety were synthesized and showed promising in vitro antioxidant and anticancer activity (Figure1). The results suggest that antioxidant activity of TCH depends on the structure, substituent type and antioxidant assay used. The maximum antioxidant activity in DPPH and CUPRAC tests was observed for compound with 8-quinolyl and 8-hydroxy-2quinolyl moiety. Additionally, anticancer assays revealed that compounds interfere with cancer cell mobility at concentrations below 10 μM, and exert low toxicity toward healthy human HaCaT fibroblasts. The results of this study represent a good foundation for further research and development of novel iminopyridines with improved antioxidant and anticancer activity.", publisher = "Hellenic Society of Medicinal Chemistry (HSMC)", journal = "18th Hellenic Symposium on Medicinal Chemistry, on-line, Greece, 25-27 February 2021", title = "Experimental study of antioxidant and anticancer activity of new asymmetrically substituted thiocarbohydrazones", pages = "P065", url = "https://hdl.handle.net/21.15107/rcub_cer_6963" }
Milošević, M., Cvijetić, I., Božić, A., Prlainović, N., Bjelogrlić, S., Popović, M.,& Marinković, A.. (2021). Experimental study of antioxidant and anticancer activity of new asymmetrically substituted thiocarbohydrazones. in 18th Hellenic Symposium on Medicinal Chemistry, on-line, Greece, 25-27 February 2021 Hellenic Society of Medicinal Chemistry (HSMC)., P065. https://hdl.handle.net/21.15107/rcub_cer_6963
Milošević M, Cvijetić I, Božić A, Prlainović N, Bjelogrlić S, Popović M, Marinković A. Experimental study of antioxidant and anticancer activity of new asymmetrically substituted thiocarbohydrazones. in 18th Hellenic Symposium on Medicinal Chemistry, on-line, Greece, 25-27 February 2021. 2021;:P065. https://hdl.handle.net/21.15107/rcub_cer_6963 .
Milošević, Milena, Cvijetić, Ilija, Božić, Aleksandra, Prlainović, Nevena, Bjelogrlić, Snežana, Popović, Mina, Marinković, Aleksandar, "Experimental study of antioxidant and anticancer activity of new asymmetrically substituted thiocarbohydrazones" in 18th Hellenic Symposium on Medicinal Chemistry, on-line, Greece, 25-27 February 2021 (2021):P065, https://hdl.handle.net/21.15107/rcub_cer_6963 .