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dc.creatorŽižak, Željko
dc.creatorJuranić, Zorica
dc.creatorOpsenica, Dejan
dc.creatorŠolaja, Bogdan
dc.creatorBesu, I.
dc.date.accessioned2019-01-30T17:23:41Z
dc.date.available2019-01-30T17:23:41Z
dc.date.issued2010
dc.identifier.issn1359-6349
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/692
dc.description.abstractIt was demonstrated that mixed steroidal tetraoxanes inhibit cancer cell proliferation at micromolar level through an apoptotic mechanism. It will be interesting to see if these compounds may possibly induce oxidative stress, which could lead to induction of apoptosis in tumour cells. As tumour cells contain more iron than other normal tissues it is reasonable to suggest that tetraoxanes could react with iron, generating alkoxy radicals or even highly reactive hydroxyl radicals in a Fenton-like reaction. To gain further insight into the mechanism of cell death induced by tetraoxane endoperoxides, we tested production of reactive oxygen species (ROS) and level of activation of caspase 3 in tumour cells treated with several newly synthesized tetraoxanes.
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.rightsopenAccess
dc.sourceEuropean Journal of Cancer Supplements
dc.subjectTetraoxanes
dc.subjectROS production
dc.subjectreactive oxygen species (ROS)
dc.subjectcancer
dc.titleTetraoxanes induced ROS production and activation of caspase 3 in HeLa cellsen
dc.typeconferenceObject
dc.rights.licenseBY-NC-ND
dcterms.abstractЈураниц, З.; Солаја, Б. A.; Опсеница, Дејан; Бесу, И.; Зизак, З.;
dc.citation.volume8
dc.citation.issue5
dc.citation.spage131
dc.citation.epage131
dc.citation.other8(5): 131-131
dc.citation.rankaM21
dc.identifier.doi10.1016/S1359-6349(10)71313-6
dc.identifier.rcubConv_2602
dc.identifier.fulltexthttp://cer.ihtm.bg.ac.rs/bitstream/id/14469/zizak2010.pdf
dc.identifier.wos000288603100495
dc.type.versionpublishedVersion


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