A Comparative Investigation of an in vitro and Clinical Test of the Bifidogenic Effect of an Infant Formula

2010
Authors
Lugonja, Nikoleta
Martinov, Olga B.
Rasovic, Mirjana R.
Spasić, Snežana

Gojgić-Cvijović, Gordana

Vrvić, Miroslav

Article (Published version)

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The bifidogenic effect of an infant formula supplemented with inulin and fructooligosaccharides (4.0 g/l) was examined clinically and in vitro, and compared that of mature breast milk. In a 28-day clinical study, fecal samples of 21 infants, divided into two groups: one receiving the infant formula and the other breast milk, were microbiologically and biochemically examined. In the in vitro investigation, microbiological and biochemical changes in the infant formula and breast milk induced by the action of bifidobacteria isolated from infant feces were examined. There were no significant differences in the fecal numbers of lactobacilli, total aerobes, anaerobes or yeasts and fungi. In contrast, the bifidobacteria numbers in the stools increased significantly during the study in the infants receiving the supplemented formula. The comparative in vitro test showed that the bifidogenic effect was similar for infant formula and breast milk in terms of the number of bifidobacteria. Consumpti...on of infant formula with added inulin and fructooligosaccharides stimulated the bifidogenic effect, both clinically and in vitro. The in vitro test can quickly and objectively determine the bifidogenic effect of infant formula and indicate their quality. However, a clinical test is necessary to determine the acceptance and biological value of infant formula.
Keywords:
infant formula / inulin / clinical examination / in vitro test / bifidogenic effectSource:
Journal of Clinical Biochemistry and Nutrition, 2010, 47, 3, 208-216Publisher:
- Journal Clinical Biochemistry & Nutrition, Kyoto
Funding / projects:
- Biomasa i metabolizam nekih mikroorganizama kao izvor široko upotrebljivih proizvoda i biohemijskih reakcija (RS-142018)
DOI: 10.3164/jcbn.10-54
ISSN: 0912-0009
PubMed: 21103029
WoS: 000286449500004
Scopus: 2-s2.0-78049483091
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IHTMTY - JOUR AU - Lugonja, Nikoleta AU - Martinov, Olga B. AU - Rasovic, Mirjana R. AU - Spasić, Snežana AU - Gojgić-Cvijović, Gordana AU - Vrvić, Miroslav PY - 2010 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/688 AB - The bifidogenic effect of an infant formula supplemented with inulin and fructooligosaccharides (4.0 g/l) was examined clinically and in vitro, and compared that of mature breast milk. In a 28-day clinical study, fecal samples of 21 infants, divided into two groups: one receiving the infant formula and the other breast milk, were microbiologically and biochemically examined. In the in vitro investigation, microbiological and biochemical changes in the infant formula and breast milk induced by the action of bifidobacteria isolated from infant feces were examined. There were no significant differences in the fecal numbers of lactobacilli, total aerobes, anaerobes or yeasts and fungi. In contrast, the bifidobacteria numbers in the stools increased significantly during the study in the infants receiving the supplemented formula. The comparative in vitro test showed that the bifidogenic effect was similar for infant formula and breast milk in terms of the number of bifidobacteria. Consumption of infant formula with added inulin and fructooligosaccharides stimulated the bifidogenic effect, both clinically and in vitro. The in vitro test can quickly and objectively determine the bifidogenic effect of infant formula and indicate their quality. However, a clinical test is necessary to determine the acceptance and biological value of infant formula. PB - Journal Clinical Biochemistry & Nutrition, Kyoto T2 - Journal of Clinical Biochemistry and Nutrition T1 - A Comparative Investigation of an in vitro and Clinical Test of the Bifidogenic Effect of an Infant Formula VL - 47 IS - 3 SP - 208 EP - 216 DO - 10.3164/jcbn.10-54 ER -
@article{ author = "Lugonja, Nikoleta and Martinov, Olga B. and Rasovic, Mirjana R. and Spasić, Snežana and Gojgić-Cvijović, Gordana and Vrvić, Miroslav", year = "2010", abstract = "The bifidogenic effect of an infant formula supplemented with inulin and fructooligosaccharides (4.0 g/l) was examined clinically and in vitro, and compared that of mature breast milk. In a 28-day clinical study, fecal samples of 21 infants, divided into two groups: one receiving the infant formula and the other breast milk, were microbiologically and biochemically examined. In the in vitro investigation, microbiological and biochemical changes in the infant formula and breast milk induced by the action of bifidobacteria isolated from infant feces were examined. There were no significant differences in the fecal numbers of lactobacilli, total aerobes, anaerobes or yeasts and fungi. In contrast, the bifidobacteria numbers in the stools increased significantly during the study in the infants receiving the supplemented formula. The comparative in vitro test showed that the bifidogenic effect was similar for infant formula and breast milk in terms of the number of bifidobacteria. Consumption of infant formula with added inulin and fructooligosaccharides stimulated the bifidogenic effect, both clinically and in vitro. The in vitro test can quickly and objectively determine the bifidogenic effect of infant formula and indicate their quality. However, a clinical test is necessary to determine the acceptance and biological value of infant formula.", publisher = "Journal Clinical Biochemistry & Nutrition, Kyoto", journal = "Journal of Clinical Biochemistry and Nutrition", title = "A Comparative Investigation of an in vitro and Clinical Test of the Bifidogenic Effect of an Infant Formula", volume = "47", number = "3", pages = "208-216", doi = "10.3164/jcbn.10-54" }
Lugonja, N., Martinov, O. B., Rasovic, M. R., Spasić, S., Gojgić-Cvijović, G.,& Vrvić, M.. (2010). A Comparative Investigation of an in vitro and Clinical Test of the Bifidogenic Effect of an Infant Formula. in Journal of Clinical Biochemistry and Nutrition Journal Clinical Biochemistry & Nutrition, Kyoto., 47(3), 208-216. https://doi.org/10.3164/jcbn.10-54
Lugonja N, Martinov OB, Rasovic MR, Spasić S, Gojgić-Cvijović G, Vrvić M. A Comparative Investigation of an in vitro and Clinical Test of the Bifidogenic Effect of an Infant Formula. in Journal of Clinical Biochemistry and Nutrition. 2010;47(3):208-216. doi:10.3164/jcbn.10-54 .
Lugonja, Nikoleta, Martinov, Olga B., Rasovic, Mirjana R., Spasić, Snežana, Gojgić-Cvijović, Gordana, Vrvić, Miroslav, "A Comparative Investigation of an in vitro and Clinical Test of the Bifidogenic Effect of an Infant Formula" in Journal of Clinical Biochemistry and Nutrition, 47, no. 3 (2010):208-216, https://doi.org/10.3164/jcbn.10-54 . .