The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.
TY - JOUR
AU - Drljevic-Djuric, K. M.
AU - Jović, Vladimir D.
AU - Lačnjevac, Uroš
AU - Avramov Ivić, Milka
AU - Petrović, Slobodan D.
AU - Mijin, Dušan
AU - Djordjevic, S. B.
PY - 2010
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/684
AB - The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.
PB - Oxford : Pergamon-Elsevier Science Ltd
T2 - Electrochimica Acta
T1 - Voltammetric and differential pulse determination of roxithromycin
VL - 56
IS - 1
SP - 47
EP - 52
DO - 10.1016/j.electacta.2010.09.067
ER -
@article{
author = "Drljevic-Djuric, K. M. and Jović, Vladimir D. and Lačnjevac, Uroš and Avramov Ivić, Milka and Petrović, Slobodan D. and Mijin, Dušan and Djordjevic, S. B.",
year = "2010",
abstract = "The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.",
publisher = "Oxford : Pergamon-Elsevier Science Ltd",
journal = "Electrochimica Acta",
title = "Voltammetric and differential pulse determination of roxithromycin",
volume = "56",
number = "1",
pages = "47-52",
doi = "10.1016/j.electacta.2010.09.067"
}
Drljevic-Djuric, K. M., Jović, V. D., Lačnjevac, U., Avramov Ivić, M., Petrović, S. D., Mijin, D.,& Djordjevic, S. B.. (2010). Voltammetric and differential pulse determination of roxithromycin. in Electrochimica Acta
Oxford : Pergamon-Elsevier Science Ltd., 56(1), 47-52.
https://doi.org/10.1016/j.electacta.2010.09.067
Drljevic-Djuric KM, Jović VD, Lačnjevac U, Avramov Ivić M, Petrović SD, Mijin D, Djordjevic SB. Voltammetric and differential pulse determination of roxithromycin. in Electrochimica Acta. 2010;56(1):47-52.
doi:10.1016/j.electacta.2010.09.067 .
Drljevic-Djuric, K. M., Jović, Vladimir D., Lačnjevac, Uroš, Avramov Ivić, Milka, Petrović, Slobodan D., Mijin, Dušan, Djordjevic, S. B., "Voltammetric and differential pulse determination of roxithromycin" in Electrochimica Acta, 56, no. 1 (2010):47-52,
https://doi.org/10.1016/j.electacta.2010.09.067 . .
