Voltammetric and differential pulse determination of roxithromycin
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AuthorsDrljevic-Djuric, K. M.
Jović, Vladimir D.
Avramov Ivić, Milka
Petrović, Slobodan D.
Djordjevic, S. B.
Article (Published version)
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The oxidative behavior of antibiotic roxithromycin standard was studied at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry and differential pulse voltammetry. It was found that the value of the oxidative peak of pure roxithromycin at 0.81 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s(-1) is a linear function of the concentration in a range 0.10006-0.654 mg cm(-3). It was also found that peak current density at 0.75 V vs. SCE at a scan rate of 2 mVs(-1), pulse amplitude of 25 mV and pulse time of 0.1 s exhibits linear dependence on the concentration of roxithromycin from 0.1006 to 0.476 mg cm(-3). Roxithromycin as a content of solid dosage form and urine was quantitatively determined and the obtained results were checked by HPLC.
Keywords:Roxithromycin / Gold electrode / Cyclic voltammetry / Differential pulse voltammetry
Source:Electrochimica Acta, 2010, 56, 1, 47-52
- Pergamon-Elsevier Science Ltd, Oxford