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Diffusion of drugs from hydrogels and liposomes as drug carriers

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2010
Authors
Pjanovic, Rada
Bošković-Vragolović, Nevenka
Veljkovic-Giga, Jelena
Garić Grulović, Radmila
Pejanovic, Srdjan
Bugarski, Branko
Article (Published version)
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Abstract
BACKGROUND: The mass transfer of model drugs Lidocaine hydrochloride and Dihydroquercetin from hydrogels (the usual carriers for topical drugs), and hydrogels containing liposomes, as novel drug vehicles, was studied. Diffusion experiments were performed using a Franz diffusion cell. Experimental data were used to calculate drug diffusion coefficients across membranes, and their effective diffusion coefficients from hydrogels and liposome containing hydrogels. For the first time the diffusion resistance of all drug carriers was determined from corresponding diffusion coefficients. The main aim of this work was the study of drug diffusion coefficients from liposomes and their comparison with related diffusion coefficients from hydrogels to find how liposomes contribute to prolonged and controlled drug release. RESULTS: Drug diffusion coefficients were: 1.38 . 10(-8)-m(2) s(-1) for Lidocaine hydrochloride and 5.96 . 10(-9)m(-2) s(-1) for Dihydroquercetin, while corresponding effective di...ffusion coefficients from hydrogels were: 7.82 . 10(-10)m(2) s(-1) and 7.98 . 10(-10)m(2) s(-1), respectively. Effective diffusion coefficients from liposome-containing hydrogels were:4.82 . 10(-10)m(2) s(-1) (Lidocaine hydrochloride) and 4.305 . 10(-10)m(2) s(-1) (Dihydroquercetin). Diffusion resistances for the two hydrogels were almost the same. Very similar values of diffusion resistances for all liposome dispersions were obtained. CONCLUSION: Calculated diffusion coefficients and resistances demonstrate that liposomes, as drug carriers, significantly affect diffusion rates. The results obtained could be used whenever diffusion-controlled drug release is required.

Keywords:
diffusion coefficient / diffusion resistance / hydrogel / liposomes / Lidocaine hydrochloride / Dihydroquercetin
Source:
Journal of Chemical Technology and Biotechnology, 2010, 85, 5, 693-698
Publisher:
  • John Wiley & Sons Ltd, Chichester

DOI: 10.1002/jctb.2357

ISSN: 0268-2575

WoS: 000277329600013

Scopus: 2-s2.0-77950808400
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URI
http://cer.ihtm.bg.ac.rs/handle/123456789/661
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