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dc.creatorStanojković, Tatjana
dc.creatorKonic-Ristic, Aleksandra
dc.creatorJuranić, Zorica
dc.creatorSavikin, Katarina
dc.creatorZdunić, Gordana
dc.creatorMenković, Nebojša
dc.creatorJadranin, Milka
dc.date.accessioned2019-01-30T17:23:00Z
dc.date.available2019-01-30T17:23:00Z
dc.date.issued2010
dc.identifier.issn1096-620X
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/659
dc.description.abstractIn recent times interest has increased in the complementary medicine of cancer patients. Two herbal mixtures were prepared from 17 and 12 plants, respectively. The goal of this study was to examine the in vitro cytotoxic and cell cycle effects of the aqueous-ethanol extracts (Extract 1 and Extract 2) obtained by maceration of the mixtures. The two extracts investigated exhibited significant antiproliferative activity toward two human breast cancer cell lines (MDA-MB-361 and MDA-MB-453) and a human cervix carcinoma cell line (HeLa) with 50% inhibitory concentration (IC(50)) values ranging from 9.92 to 17.38 mu L/mL. The extracts did not exert any significant cytotoxicity toward healthy human peripheral blood mononuclear cells. In vitro antitumor activites were accompanied by an important apoptotic fraction of all cell lines after treatment with the extracts. The amount of total phenols was similar in both extracts, whereas the concentration of total tannins was significantly higher in Extract 1. Extract 1 was also found to be a stronger free radical scavenger, with an IC(50) value of 13.4 mu g/mL. Both extracts contained rosmarinic acid, while ursolic acid was identified in Extract 2.en
dc.publisherMary Ann Liebert Inc, New Rochelle
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Medicinal Food
dc.subjectapoptosisen
dc.subject1,1-diphenyl-2-picrylhydrazylen
dc.subjectHeLaen
dc.subjectMDA-MB-361en
dc.subjectMDA-MB-453en
dc.subjectperipheral blood mononuclear cellsen
dc.subjectphenolicsen
dc.titleCytotoxic and Cell Cycle Effects Induced by Two Herbal Extracts on Human Cervix Carcinoma and Human Breast Cancer Cell Linesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈураниц, Зорица Д.; Менковиц, Небојса; Јадранин, Милка; Станојковиц, Татјана П.; Здуниц, Гордана; Кониц-Ристиц, Aлександра; Савикин, Катарина;
dc.citation.volume13
dc.citation.issue2
dc.citation.spage291
dc.citation.epage297
dc.citation.other13(2): 291-297
dc.citation.rankM22
dc.identifier.pmid20170382
dc.identifier.doi10.1089/jmf.2009.0086
dc.identifier.rcubConv_2506
dc.identifier.scopus2-s2.0-77958183263
dc.identifier.wos000277190700008
dc.type.versionpublishedVersion


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