The paramagnetic pillared bentonites as digestive tract mri contrast agents
Authorized Users Only
Milutinović Nikolić, Aleksandra
Jovanović, Dušan M.
Article (Published version)
MetadataShow full item record
The increased use of imaging techniques in diagnostic studies, such as MRI, has contributed to the development of the wide range of new materials which could be successfully used as image improving agents. However, there is a lack of such substances in the area of gastrointestinal tract MRI. Many of the traditionally popular relaxation altering agents show poor results and disadvantages provoking black bowel, side effects of diarrhea and the presence of artifacts arising from clumping. Paramagnetic species seem to be potentially suitable agents for these studies, but contrast opacification has been reported and less than 60% of the gastrointestinal tract magnetic resonance scans showed improved delineation of abdominal pathologies. The new solution has been proposed as zeolites or smectite clays (hectorite and montmorillonite) enclosing of paramagnetic metal ions obtained by ion-exchange methods. However, such materials have problems of leakage of paramagnetic ions causing the appearan...ce of the various side-effects. In this study we show that Co(+2) and Dy(+3) paramagnetic-pillared bentonites could be successfully used as MRI digestive tract non-leaching contrast agents, altering the longitudinal and transverse relaxation times of fluids in contact with the clay minerals.
Keywords:Bentonites / pillaring / MRI contrast / digestive tract
Source:International Journal of Modern Physics B, 2010, 24, 6-7, 780-787
- World Scientific Publ Co Pte Ltd, Singapore
- Sinteza, karakterizacija i testiranje katalitičkih svojstava specijalno dizajniranih materijala (RS-142019)
- Biofizička istraživanja membranskih procesa: interakcija membranskih receptora i kanala sa spoljašnjim faktorima i intracelularna regulacija (RS-143016)
- Mezoporozni i nanomaterijali u katalitičkim i sorpcionim procesima (RS-166001)