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Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Ivanovic, Ivanka | |
dc.creator | Rakic, Gordana | |
dc.creator | Todorović, Nina | |
dc.creator | Gligorijević, Nevenka | |
dc.creator | Radulovic, Sinisa | |
dc.creator | Arion, Vladimir B. | |
dc.creator | Keppler, Bernhard K. | |
dc.creator | Tešić, Živoslav | |
dc.date.accessioned | 2019-01-30T17:22:41Z | |
dc.date.available | 2019-01-30T17:22:41Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | https://cer.ihtm.bg.ac.rs/handle/123456789/646 | |
dc.description.abstract | Ruthenium(II)-arene complexes of general formulae [(eta(6)-p-cymene)Ru(L1-3)Cl-2], where L1-3 is 3-acetylpyridine (1), 4-acetylpyridine (2) and 2-amino-5-chloropyridine (3), Correspondingly, [(eta(6)-p-cymene)Ru(HL4,5)Cl-2], where HL4 and HL5 are respectively isonicotinic acid (4) and nicotinic acid (5) and [(eta(6)-p-cymene)Ru(HL6-9)Cl], where H2L6-9 represent 2,3-pyridinedicarboxylic acid (6), 2,4-pyidinedicarboxylic acid (7), 2,5-pyridinedicarboxylic acid (8) and 2,6-pyridinedicarboxylic acid (9), were prepared by the reaction of (eta(6)-p-cymene)(2)RuCl2](2) (10) with the corresponding ligand in 1:2 molar ratio in isopropanol. The complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies. According to these data the molecules adopt the usual "three-leg piano-stool" geometry which is common for this type of complexes. The structures of I and 7 were determined by X-ray crystallography. The complexes revealed low antiproliferative activity in six investigated tumor cell lines (HeLa, B16, FemX, MDA-MB-361, MDA-MB-453 and LS-174). The reaction of 6 with 9-methyladenine was studied by H-1 NMR, H-1, H-1 COSY and H-1, H-1 NOESY spectroscopy. | en |
dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142062/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145035/RS// | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Medicinal Chemistry | |
dc.subject | Ruthenium(II)-arene | en |
dc.subject | Pyridine derivatives | en |
dc.subject | Cytotoxicity | en |
dc.title | Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Гргурић-Шипка, Сања; Радуловиц, Синиса; Ракиц, Гордана; Глигоријевиц, Невенка; Aрион, Владимир Б.; Кепплер, Бернхард К.; Тесиц, Зивослав Љ.; Ивановиц, Иванка; Тодоровић, Нина; | |
dc.citation.volume | 45 | |
dc.citation.issue | 3 | |
dc.citation.spage | 1051 | |
dc.citation.epage | 1058 | |
dc.citation.other | 45(3): 1051-1058 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 20053483 | |
dc.identifier.doi | 10.1016/j.ejmech.2009.11.055 | |
dc.identifier.scopus | 2-s2.0-75949128866 | |
dc.identifier.wos | 000275404900024 | |
dc.type.version | publishedVersion |