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dc.creatorGrgurić-Šipka, Sanja
dc.creatorIvanovic, Ivanka
dc.creatorRakic, Gordana
dc.creatorTodorović, Nina
dc.creatorGligorijević, Nevenka
dc.creatorRadulovic, Sinisa
dc.creatorArion, Vladimir B.
dc.creatorKeppler, Bernhard K.
dc.creatorTešić, Živoslav
dc.date.accessioned2019-01-30T17:22:41Z
dc.date.available2019-01-30T17:22:41Z
dc.date.issued2010
dc.identifier.issn0223-5234
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/646
dc.description.abstractRuthenium(II)-arene complexes of general formulae [(eta(6)-p-cymene)Ru(L1-3)Cl-2], where L1-3 is 3-acetylpyridine (1), 4-acetylpyridine (2) and 2-amino-5-chloropyridine (3), Correspondingly, [(eta(6)-p-cymene)Ru(HL4,5)Cl-2], where HL4 and HL5 are respectively isonicotinic acid (4) and nicotinic acid (5) and [(eta(6)-p-cymene)Ru(HL6-9)Cl], where H2L6-9 represent 2,3-pyridinedicarboxylic acid (6), 2,4-pyidinedicarboxylic acid (7), 2,5-pyridinedicarboxylic acid (8) and 2,6-pyridinedicarboxylic acid (9), were prepared by the reaction of (eta(6)-p-cymene)(2)RuCl2](2) (10) with the corresponding ligand in 1:2 molar ratio in isopropanol. The complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies. According to these data the molecules adopt the usual "three-leg piano-stool" geometry which is common for this type of complexes. The structures of I and 7 were determined by X-ray crystallography. The complexes revealed low antiproliferative activity in six investigated tumor cell lines (HeLa, B16, FemX, MDA-MB-361, MDA-MB-453 and LS-174). The reaction of 6 with 9-methyladenine was studied by H-1 NMR, H-1, H-1 COSY and H-1, H-1 NOESY spectroscopy.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145035/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectRuthenium(II)-areneen
dc.subjectPyridine derivativesen
dc.subjectCytotoxicityen
dc.titleRuthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activityen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГргурић-Шипка, Сања; Радуловиц, Синиса; Ракиц, Гордана; Глигоријевиц, Невенка; Aрион, Владимир Б.; Кепплер, Бернхард К.; Тесиц, Зивослав Љ.; Ивановиц, Иванка; Тодоровић, Нина;
dc.citation.volume45
dc.citation.issue3
dc.citation.spage1051
dc.citation.epage1058
dc.citation.other45(3): 1051-1058
dc.citation.rankM21
dc.identifier.pmid20053483
dc.identifier.doi10.1016/j.ejmech.2009.11.055
dc.identifier.rcubConv_2490
dc.identifier.scopus2-s2.0-75949128866
dc.identifier.wos000275404900024
dc.type.versionpublishedVersion


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