Ultradian oscillations of corticotropin-releasing hormone (crh) and arginine vasopressin (avp) in modelling of hypothalamic-pituitary-adrenal axis: influence of feedback loop between crh and cortisol
Autori
Stojiljković, AleksandraČupić, Željko
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Maćešić, Stevan
![](/themes/MirageCER/images/orcid.png)
Ivanović-Šašić, Ana
![](/themes/MirageCER/images/orcid.png)
Kolar-Anić, Ljiljana
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Konferencijski prilog (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The previously proposed stoichiometric model of the Hypothalamic-Pituitary-Adrenal (HPA)
axis activity that took into account arginine vasopressin (AVP), has been further developed to
emulate ultradian oscillations of corticotropin-releasing hormone (CRH) and AVP. With this
aim, additional coupling of HPA consisting hormones was introduced into this model by
reaction between CRH and cortisol (CORT). How additional coupling of hormones affects HPA
axis ultradian dynamics and reflects on ultradian oscillations of AVP and CRH concentrations
was examined by using numerical simulations and bifurcation analysis. Results show that the
rate constant of newly incorporated reaction alone is sufficient to be adjusted only for CRH to
exhibit oscillations with optimally prominent amplitudes. Also, oscillation frequencies of CRH
were found to be in accordance with findings in the literature under all investigated conditions
Ključne reči:
Hypothalamic-Pituitary-Adrenal (HPA) axis / ultradian dynamicsIzvor:
Proceedings - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Physical Chemistry 2022, September, 26-30, 2022, Belgrade, Serbia, 2022, I, 207-210Izdavač:
- Society of Physical Chemists of Serbia
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200026 (Univerzitet u Beogradu, Institut za hemiju, tehnologiju i metalurgiju - IHTM) (RS-MESTD-inst-2020-200026)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200051 (Institut za opštu i fizičku hemiju, Beograd) (RS-MESTD-inst-2020-200051)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200146 (Univerzitet u Beogradu, Fakultet za fizičku hemiju) (RS-MESTD-inst-2020-200146)
Institucija/grupa
IHTMTY - CONF AU - Stojiljković, Aleksandra AU - Čupić, Željko AU - Maćešić, Stevan AU - Ivanović-Šašić, Ana AU - Kolar-Anić, Ljiljana PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6413 AB - The previously proposed stoichiometric model of the Hypothalamic-Pituitary-Adrenal (HPA) axis activity that took into account arginine vasopressin (AVP), has been further developed to emulate ultradian oscillations of corticotropin-releasing hormone (CRH) and AVP. With this aim, additional coupling of HPA consisting hormones was introduced into this model by reaction between CRH and cortisol (CORT). How additional coupling of hormones affects HPA axis ultradian dynamics and reflects on ultradian oscillations of AVP and CRH concentrations was examined by using numerical simulations and bifurcation analysis. Results show that the rate constant of newly incorporated reaction alone is sufficient to be adjusted only for CRH to exhibit oscillations with optimally prominent amplitudes. Also, oscillation frequencies of CRH were found to be in accordance with findings in the literature under all investigated conditions PB - Society of Physical Chemists of Serbia C3 - Proceedings - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Physical Chemistry 2022, September, 26-30, 2022, Belgrade, Serbia T1 - Ultradian oscillations of corticotropin-releasing hormone (crh) and arginine vasopressin (avp) in modelling of hypothalamic-pituitary-adrenal axis: influence of feedback loop between crh and cortisol VL - I SP - 207 EP - 210 UR - https://hdl.handle.net/21.15107/rcub_cer_6413 ER -
@conference{ author = "Stojiljković, Aleksandra and Čupić, Željko and Maćešić, Stevan and Ivanović-Šašić, Ana and Kolar-Anić, Ljiljana", year = "2022", abstract = "The previously proposed stoichiometric model of the Hypothalamic-Pituitary-Adrenal (HPA) axis activity that took into account arginine vasopressin (AVP), has been further developed to emulate ultradian oscillations of corticotropin-releasing hormone (CRH) and AVP. With this aim, additional coupling of HPA consisting hormones was introduced into this model by reaction between CRH and cortisol (CORT). How additional coupling of hormones affects HPA axis ultradian dynamics and reflects on ultradian oscillations of AVP and CRH concentrations was examined by using numerical simulations and bifurcation analysis. Results show that the rate constant of newly incorporated reaction alone is sufficient to be adjusted only for CRH to exhibit oscillations with optimally prominent amplitudes. Also, oscillation frequencies of CRH were found to be in accordance with findings in the literature under all investigated conditions", publisher = "Society of Physical Chemists of Serbia", journal = "Proceedings - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Physical Chemistry 2022, September, 26-30, 2022, Belgrade, Serbia", title = "Ultradian oscillations of corticotropin-releasing hormone (crh) and arginine vasopressin (avp) in modelling of hypothalamic-pituitary-adrenal axis: influence of feedback loop between crh and cortisol", volume = "I", pages = "207-210", url = "https://hdl.handle.net/21.15107/rcub_cer_6413" }
Stojiljković, A., Čupić, Ž., Maćešić, S., Ivanović-Šašić, A.,& Kolar-Anić, L.. (2022). Ultradian oscillations of corticotropin-releasing hormone (crh) and arginine vasopressin (avp) in modelling of hypothalamic-pituitary-adrenal axis: influence of feedback loop between crh and cortisol. in Proceedings - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Physical Chemistry 2022, September, 26-30, 2022, Belgrade, Serbia Society of Physical Chemists of Serbia., I, 207-210. https://hdl.handle.net/21.15107/rcub_cer_6413
Stojiljković A, Čupić Ž, Maćešić S, Ivanović-Šašić A, Kolar-Anić L. Ultradian oscillations of corticotropin-releasing hormone (crh) and arginine vasopressin (avp) in modelling of hypothalamic-pituitary-adrenal axis: influence of feedback loop between crh and cortisol. in Proceedings - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Physical Chemistry 2022, September, 26-30, 2022, Belgrade, Serbia. 2022;I:207-210. https://hdl.handle.net/21.15107/rcub_cer_6413 .
Stojiljković, Aleksandra, Čupić, Željko, Maćešić, Stevan, Ivanović-Šašić, Ana, Kolar-Anić, Ljiljana, "Ultradian oscillations of corticotropin-releasing hormone (crh) and arginine vasopressin (avp) in modelling of hypothalamic-pituitary-adrenal axis: influence of feedback loop between crh and cortisol" in Proceedings - 16th International Conference on Fundamental and Applied Aspects of Physical Chemistry, Physical Chemistry 2022, September, 26-30, 2022, Belgrade, Serbia, I (2022):207-210, https://hdl.handle.net/21.15107/rcub_cer_6413 .