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dc.creatorBjelogrlić, Snežana K.
dc.creatorTodorović, Tamara
dc.creatorBacchi, Alessia
dc.creatorZec, Manja
dc.creatorSladić, Dušan
dc.creatorSrdic-Rajic, Tatjana
dc.creatorRadanović, Dušanka
dc.creatorRadulovic, Sinisa
dc.creatorPelizzi, Giancarlo
dc.creatorAnđelković, Katarina
dc.date.accessioned2019-01-30T17:22:18Z
dc.date.available2019-01-30T17:22:18Z
dc.date.issued2010
dc.identifier.issn0162-0134
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/631
dc.description.abstractTwo novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145035/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Inorganic Biochemistry
dc.subjectZn(II) and Cd(II) complexesen
dc.subjectSelenosemicarbazonesen
dc.subjectX-ray analysisen
dc.subjectNMR spectroscopyen
dc.subjectAntiproliferative activityen
dc.subjectApoptosisen
dc.titleSynthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБјелогрлић, Снежана К.; Баццхи, Aлессиа; Aнђелковиц, Катарина; Тодоровић, Тамара Р.; Пелиззи, Гианцарло; Радуловиц, Синиса; Сладиц, Дусан; Радановић, Душанка; Зец, Мања; Срдиц-Рајиц, Татјана;
dc.citation.volume104
dc.citation.issue6
dc.citation.spage673
dc.citation.epage682
dc.citation.other104(6): 673-682
dc.citation.rankM21
dc.identifier.pmid20356629
dc.identifier.doi10.1016/j.jinorgbio.2010.02.009
dc.identifier.rcubConv_2514
dc.identifier.scopus2-s2.0-77952553954
dc.identifier.wos000277946300008
dc.type.versionpublishedVersion


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