Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 ± 11.66%) and gastroprotective activity (gastric damage score of 0.21 ± 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (129 ± 9 μg/mL and 52 ± 4 μg/mL, respectively). Quercet...in and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an anti-inflammatory and gastroprotective agent, which has been based previously only on ethnopharmacological claims. Copyright
TY - JOUR
AU - Zdunić, Gordana
AU - Gođevac, Dejan
AU - Milenković, Marina
AU - Vučićević, D.
AU - Šavikin, Katarina
AU - Menković, Nebojša
AU - Petrović, S.
PY - 2009
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/625
AB - Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 ± 11.66%) and gastroprotective activity (gastric damage score of 0.21 ± 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (129 ± 9 μg/mL and 52 ± 4 μg/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an anti-inflammatory and gastroprotective agent, which has been based previously only on ethnopharmacological claims. Copyright
T2 - Phytotherapy Research
T1 - Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats
VL - 23
IS - 11
SP - 1559
EP - 1564
DO - 10.1002/ptr.2809
ER -
@article{
author = "Zdunić, Gordana and Gođevac, Dejan and Milenković, Marina and Vučićević, D. and Šavikin, Katarina and Menković, Nebojša and Petrović, S.",
year = "2009",
abstract = "Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated in the obtained oil extracts. The carrageenan-induced rat paw edema test has been used for screening the antiinflammatory activity, while the indomethacin-induced rat gastric mucosa damage test was used for evaluation of gastroprotective activity. All examined oil extracts possessed antiinflammatory and gastroprotective activity. Among them, the oil extract prepared by maceration with 96% ethanol, followed by extraction with sunflower oil by heating on a water bath (extract 2), in a dose of 1.25 mL/kg p.o., exhibited the highest antiinflammatory effect (95.24 ± 11.66%) and gastroprotective activity (gastric damage score of 0.21 ± 0.12). The same oil extract had the highest content of quercetin and I3,II8-biapigenin (129 ± 9 μg/mL and 52 ± 4 μg/mL, respectively). Quercetin and I3,II8-biapigenin exhibited antiinflammatory activity similar to those of indomethacin as well as significant gastroprotective activity. The results provide evidence for the usage of Oleum Hyperici as an anti-inflammatory and gastroprotective agent, which has been based previously only on ethnopharmacological claims. Copyright",
journal = "Phytotherapy Research",
title = "Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats",
volume = "23",
number = "11",
pages = "1559-1564",
doi = "10.1002/ptr.2809"
}
Zdunić, G., Gođevac, D., Milenković, M., Vučićević, D., Šavikin, K., Menković, N.,& Petrović, S.. (2009). Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. in Phytotherapy Research, 23(11), 1559-1564.
https://doi.org/10.1002/ptr.2809
Zdunić G, Gođevac D, Milenković M, Vučićević D, Šavikin K, Menković N, Petrović S. Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats. in Phytotherapy Research. 2009;23(11):1559-1564.
doi:10.1002/ptr.2809 .
Zdunić, Gordana, Gođevac, Dejan, Milenković, Marina, Vučićević, D., Šavikin, Katarina, Menković, Nebojša, Petrović, S., "Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats" in Phytotherapy Research, 23, no. 11 (2009):1559-1564,
https://doi.org/10.1002/ptr.2809 . .
