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dc.creatorŽižak, Željko
dc.creatorJuranić, Zorica
dc.creatorOpsenica, Dejan
dc.creatorŠolaja, Bogdan
dc.date.accessioned2019-01-30T17:22:12Z
dc.date.available2019-01-30T17:22:12Z
dc.date.issued2009
dc.identifier.issn0167-6997
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/624
dc.description.abstractIn this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145006/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142022/RS//
dc.rightsrestrictedAccess
dc.sourceInvestigational New Drugs
dc.subjectAnticancer agentsen
dc.subjectApoptosisen
dc.subjectcytotoxicityen
dc.subjectTetraoxanesen
dc.titleMixed steroidal tetraoxanes induce apoptotic cell death in tumor cellsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈуранић, З.; Шолаја, Б.A.; Жижак, Ж.; Опсеница, Дејан;
dc.citation.volume27
dc.citation.issue5
dc.citation.spage432
dc.citation.epage439
dc.citation.other27(5): 432-439
dc.citation.rankM22
dc.identifier.pmid19011761
dc.identifier.doi10.1007/s10637-008-9197-1
dc.identifier.rcubConv_4217
dc.identifier.scopus2-s2.0-70349248154
dc.identifier.wos000269884100005
dc.type.versionpublishedVersion


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