Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells

Žižak, Željko; Juranić, Zorica; Opsenica, Dejan; Šolaja, Bogdan

doi:10.1007/s10637-008-9197-1

Samo za registrovane korisnike

2009

Autori

Žižak, Željko

Juranić, Zorica

Opsenica, Dejan

Šolaja, Bogdan

Članak u časopisu (Objavljena verzija)

Metapodaci

Prikaz svih podataka o dokumentu

Apstrakt

In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.

Ključne reči:

Anticancer agents / Apoptosis / cytotoxicity / Tetraoxanes

Izvor:
Investigational New Drugs, 2009, 27, 5, 432-439

Finansiranje / projekti:

DOI: 10.1007/s10637-008-9197-1

ISSN: 0167-6997

PubMed: 19011761

WoS: 000269884100005

Scopus: 2-s2.0-70349248154

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TY  - JOUR
AU  - Žižak, Željko
AU  - Juranić, Zorica
AU  - Opsenica, Dejan
AU  - Šolaja, Bogdan
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/624
AB  - In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.
T2  - Investigational New Drugs
T1  - Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells
VL  - 27
IS  - 5
SP  - 432
EP  - 439
DO  - 10.1007/s10637-008-9197-1
ER  -

@article{
author = "Žižak, Željko and Juranić, Zorica and Opsenica, Dejan and Šolaja, Bogdan",
year = "2009",
abstract = "In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.",
journal = "Investigational New Drugs",
title = "Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells",
volume = "27",
number = "5",
pages = "432-439",
doi = "10.1007/s10637-008-9197-1"
}

Žižak, Ž., Juranić, Z., Opsenica, D.,& Šolaja, B.. (2009). Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells. in Investigational New Drugs, 27(5), 432-439.
https://doi.org/10.1007/s10637-008-9197-1

Žižak Ž, Juranić Z, Opsenica D, Šolaja B. Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells. in Investigational New Drugs. 2009;27(5):432-439.
doi:10.1007/s10637-008-9197-1 .

Žižak, Željko, Juranić, Zorica, Opsenica, Dejan, Šolaja, Bogdan, "Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells" in Investigational New Drugs, 27, no. 5 (2009):432-439,
https://doi.org/10.1007/s10637-008-9197-1 . .