Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety
Само за регистроване кориснике
2009
Аутори
Joksović, M.D.Marković, V.
Juranić, Zorica
Stanojković, Tatjana
Jovanović, L.S.
Damljanović, I.S.
Szécsényi, K.M.
Todorović, Nina
Trifunović, Snežana
Vukićević, Rastko
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.
Кључне речи:
Amino acids / cytotoxicity / Ferrocenyl pyrazoleИзвор:
Journal of Organometallic Chemistry, 2009, 694, 24, 3935-3942Финансирање / пројекти:
- Синтезе, физичке, структурне и биолошке карактеристике нових комплексних једењења (RS-MESTD-MPN2006-2010-142028)
- Развој нових електрохемијских и хемијских метода органске синтезе (RS-MESTD-MPN2006-2010-142042)
- Истраживање дејстава модификатора биолошког одговора у физиолошким и патолошким стањима (RS-MESTD-MPN2006-2010-145006)
DOI: 10.1016/j.jorganchem.2009.08.013
ISSN: 0022-328X
WoS: 000271099300015
Scopus: 2-s2.0-70349999659
Институција/група
IHTMTY - JOUR AU - Joksović, M.D. AU - Marković, V. AU - Juranić, Zorica AU - Stanojković, Tatjana AU - Jovanović, L.S. AU - Damljanović, I.S. AU - Szécsényi, K.M. AU - Todorović, Nina AU - Trifunović, Snežana AU - Vukićević, Rastko PY - 2009 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/619 AB - A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. T2 - Journal of Organometallic Chemistry T1 - Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety VL - 694 IS - 24 SP - 3935 EP - 3942 DO - 10.1016/j.jorganchem.2009.08.013 ER -
@article{ author = "Joksović, M.D. and Marković, V. and Juranić, Zorica and Stanojković, Tatjana and Jovanović, L.S. and Damljanović, I.S. and Szécsényi, K.M. and Todorović, Nina and Trifunović, Snežana and Vukićević, Rastko", year = "2009", abstract = "A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.", journal = "Journal of Organometallic Chemistry", title = "Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety", volume = "694", number = "24", pages = "3935-3942", doi = "10.1016/j.jorganchem.2009.08.013" }
Joksović, M.D., Marković, V., Juranić, Z., Stanojković, T., Jovanović, L.S., Damljanović, I.S., Szécsényi, K.M., Todorović, N., Trifunović, S.,& Vukićević, R.. (2009). Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry, 694(24), 3935-3942. https://doi.org/10.1016/j.jorganchem.2009.08.013
Joksović M, Marković V, Juranić Z, Stanojković T, Jovanović L, Damljanović I, Szécsényi K, Todorović N, Trifunović S, Vukićević R. Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry. 2009;694(24):3935-3942. doi:10.1016/j.jorganchem.2009.08.013 .
Joksović, M.D., Marković, V., Juranić, Zorica, Stanojković, Tatjana, Jovanović, L.S., Damljanović, I.S., Szécsényi, K.M., Todorović, Nina, Trifunović, Snežana, Vukićević, Rastko, "Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety" in Journal of Organometallic Chemistry, 694, no. 24 (2009):3935-3942, https://doi.org/10.1016/j.jorganchem.2009.08.013 . .