Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety
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2009
Authors
Joksović, M.D.Marković, V.

Juranić, Zorica

Stanojković, Tatjana

Jovanović, L.S.
Damljanović, I.S.
Szécsényi, K.M.
Todorović, Nina

Trifunović, Snežana

Vukićević, Rastko

Article (Published version)

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A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.
Keywords:
Amino acids / cytotoxicity / Ferrocenyl pyrazoleSource:
Journal of Organometallic Chemistry, 2009, 694, 24, 3935-3942Funding / projects:
- Sinteze, fizičke, strukturne i biološke karakteristike novih kompleksnih jedenjenja (RS-142028)
- Razvoj novih elektrohemijskih i hemijskih metoda organske sinteze (RS-142042)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)
DOI: 10.1016/j.jorganchem.2009.08.013
ISSN: 0022-328X
WoS: 000271099300015
Scopus: 2-s2.0-70349999659
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IHTMTY - JOUR AU - Joksović, M.D. AU - Marković, V. AU - Juranić, Zorica AU - Stanojković, Tatjana AU - Jovanović, L.S. AU - Damljanović, I.S. AU - Szécsényi, K.M. AU - Todorović, Nina AU - Trifunović, Snežana AU - Vukićević, Rastko PY - 2009 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/619 AB - A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. T2 - Journal of Organometallic Chemistry T1 - Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety VL - 694 IS - 24 SP - 3935 EP - 3942 DO - 10.1016/j.jorganchem.2009.08.013 ER -
@article{ author = "Joksović, M.D. and Marković, V. and Juranić, Zorica and Stanojković, Tatjana and Jovanović, L.S. and Damljanović, I.S. and Szécsényi, K.M. and Todorović, Nina and Trifunović, Snežana and Vukićević, Rastko", year = "2009", abstract = "A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.", journal = "Journal of Organometallic Chemistry", title = "Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety", volume = "694", number = "24", pages = "3935-3942", doi = "10.1016/j.jorganchem.2009.08.013" }
Joksović, M.D., Marković, V., Juranić, Z., Stanojković, T., Jovanović, L.S., Damljanović, I.S., Szécsényi, K.M., Todorović, N., Trifunović, S.,& Vukićević, R.. (2009). Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry, 694(24), 3935-3942. https://doi.org/10.1016/j.jorganchem.2009.08.013
Joksović M, Marković V, Juranić Z, Stanojković T, Jovanović L, Damljanović I, Szécsényi K, Todorović N, Trifunović S, Vukićević R. Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry. 2009;694(24):3935-3942. doi:10.1016/j.jorganchem.2009.08.013 .
Joksović, M.D., Marković, V., Juranić, Zorica, Stanojković, Tatjana, Jovanović, L.S., Damljanović, I.S., Szécsényi, K.M., Todorović, Nina, Trifunović, Snežana, Vukićević, Rastko, "Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety" in Journal of Organometallic Chemistry, 694, no. 24 (2009):3935-3942, https://doi.org/10.1016/j.jorganchem.2009.08.013 . .