Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety
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2009
Authors
Joksović, M.D.Marković, V.

Juranić, Zorica

Stanojković, Tatjana

Jovanović, L.S.
Damljanović, I.S.
Szécsényi, K.M.
Todorović, Nina

Trifunović, Snežana

Vukićević, R.D.
Article (Published version)

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Show full item recordAbstract
A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.
Keywords:
Amino acids / cytotoxicity / Ferrocenyl pyrazoleSource:
Journal of Organometallic Chemistry, 2009, 694, 24, 3935-3942Projects:
- Sinteze, fizičke, strukturne i biološke karakteristike novih kompleksnih jedenjenja (RS-142028)
- Razvoj novih elektrohemijskih i hemijskih metoda organske sinteze (RS-142042)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)
DOI: 10.1016/j.jorganchem.2009.08.013
ISSN: 0022-328X