CER - Central Repository
Institute of Chemistry, Technology and Metallurgy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
  •   CER
  • IHTM
  • Radovi istraživača / Researchers' publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety

Authorized Users Only
2009
Authors
Joksović, M.D.
Marković, V.
Juranić, Zorica
Stanojković, Tatjana
Jovanović, L.S.
Damljanović, I.S.
Szécsényi, K.M.
Todorović, Nina
Trifunović, Snežana
Vukićević, Rastko
Article (Published version)
Metadata
Show full item record
Abstract
A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.
Keywords:
Amino acids / cytotoxicity / Ferrocenyl pyrazole
Source:
Journal of Organometallic Chemistry, 2009, 694, 24, 3935-3942
Funding / projects:
  • Sinteze, fizičke, strukturne i biološke karakteristike novih kompleksnih jedenjenja (RS-142028)
  • Razvoj novih elektrohemijskih i hemijskih metoda organske sinteze (RS-142042)
  • Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)

DOI: 10.1016/j.jorganchem.2009.08.013

ISSN: 0022-328X

WoS: 000271099300015

Scopus: 2-s2.0-70349999659
[ Google Scholar ]
65
62
URI
https://cer.ihtm.bg.ac.rs/handle/123456789/619
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
IHTM
TY  - JOUR
AU  - Joksović, M.D.
AU  - Marković, V.
AU  - Juranić, Zorica
AU  - Stanojković, Tatjana
AU  - Jovanović, L.S.
AU  - Damljanović, I.S.
AU  - Szécsényi, K.M.
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Vukićević, Rastko
PY  - 2009
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/619
AB  - A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety
VL  - 694
IS  - 24
SP  - 3935
EP  - 3942
DO  - 10.1016/j.jorganchem.2009.08.013
ER  - 
@article{
author = "Joksović, M.D. and Marković, V. and Juranić, Zorica and Stanojković, Tatjana and Jovanović, L.S. and Damljanović, I.S. and Szécsényi, K.M. and Todorović, Nina and Trifunović, Snežana and Vukićević, Rastko",
year = "2009",
abstract = "A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] α-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 1l exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines.",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety",
volume = "694",
number = "24",
pages = "3935-3942",
doi = "10.1016/j.jorganchem.2009.08.013"
}
Joksović, M.D., Marković, V., Juranić, Z., Stanojković, T., Jovanović, L.S., Damljanović, I.S., Szécsényi, K.M., Todorović, N., Trifunović, S.,& Vukićević, R.. (2009). Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry, 694(24), 3935-3942.
https://doi.org/10.1016/j.jorganchem.2009.08.013
Joksović M, Marković V, Juranić Z, Stanojković T, Jovanović L, Damljanović I, Szécsényi K, Todorović N, Trifunović S, Vukićević R. Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry. 2009;694(24):3935-3942.
doi:10.1016/j.jorganchem.2009.08.013 .
Joksović, M.D., Marković, V., Juranić, Zorica, Stanojković, Tatjana, Jovanović, L.S., Damljanović, I.S., Szécsényi, K.M., Todorović, Nina, Trifunović, Snežana, Vukićević, Rastko, "Synthesis, characterization and antitumor activity of novel N-substituted α-amino acids containing ferrocenyl pyrazole-moiety" in Journal of Organometallic Chemistry, 694, no. 24 (2009):3935-3942,
https://doi.org/10.1016/j.jorganchem.2009.08.013 . .

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB
 

 

All of DSpaceInstitutions/communitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About CeR – Central Repository | Send Feedback

re3dataOpenAIRERCUB