Electrochemical determination of duloxetine hydrochloride at gold electrode

Abstract

Duloxetine hydrochloride ( D U L ) , a naphth) I ether amine, inhibits the uptake of serotonin and norepinephrine. The electrochemical behavior of D U L was determined by cyclic voltammetry ( C V ) in phosphate buffer solution at gold electrode by varying pH and scan rate. The electroanalytical application was studied with the aid of differential pulse voltammetry (DPV) in sodium bicarbonate solution. A linear response ranged from 5x10'^ M to 10'" M. The validation of the DPV method was carried out by determine of the limit of detection (LOD) and limit of quantitation (LOQ) and the calculate values were 4.6 X 10"'' and 2 x 10'^' M, respective!). The proposed DPV method has been successfully applied to assessment DUL as standard and in Taita® tablets and standard spiked with human serum.