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dc.creatorHarhaji-Trajković, Ljubica
dc.creatorMijatović, Sanja
dc.creatorMaksimović-Ivanić, Danijela D.
dc.creatorStojanovic, I.D.
dc.creatorMomcilovic, M.B.
dc.creatorTufegdžić, Srđan
dc.creatorMaksimović, Vesna M.
dc.creatorMarjanovi, Z.S.
dc.creatorStosic-Grujicic, S.D.
dc.date.accessioned2019-01-30T17:22:01Z
dc.date.available2019-01-30T17:22:01Z
dc.date.issued2009
dc.identifier.issn0163-5581
dc.identifier.urihttp://cer.ihtm.bg.ac.rs/handle/123456789/616
dc.description.abstractAnticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in vitro, whereby GLme exhibited stronger effect. Furthermore, anticancer activity of GLme was demonstrated for the first time against two other rodent tumor cell lines, L929-mouse fibrosarcoma and C6-rat astrocytoma. The mechanism of antitumor activity of GLme comprised inhibition of cell proliferation and induction of caspase-dependent apoptotic cell death mediated by upregulated p53 and inhibited Bcl-2 expression. Moreover, the antitumor effect of the GLme was associated with intensified production of reactive oxygen species, whereas their neutralization by the antioxidant, N-acetyl cysteine, resulted in partial recovery of cell viability. Thus, our results suggest that GLme might be a good candidate for treatment of diverse forms of cancers.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143029/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143016/RS//
dc.rightsrestrictedAccess
dc.sourceNutrition and Cancer
dc.titleAnticancer properties of ganoderma lucidum methanol extracts in vitro and in vivoen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТуфегджић, Срђан; Стосиц-Грујициц, С.Д.; Марјанови, З.С.; Максимовић, Весна М.; Момциловиц, М.Б.; Максимовиц-Иваниц, Д.Д.; Стојановиц, И.Д.; Мијатовиц, С.A.; Хархаји, Трајковиц Л.М.;
dc.citation.volume61
dc.citation.issue5
dc.citation.spage696
dc.citation.epage707
dc.citation.other61(5): 696-707
dc.citation.rankM22
dc.identifier.pmid19838944
dc.identifier.doi10.1080/01635580902898743
dc.identifier.rcubConv_4225
dc.identifier.scopus2-s2.0-70449625691
dc.identifier.wos000270427100015
dc.type.versionpublishedVersion


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