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Closer look into HIV-host interactions: Standard Gibbs energy of binding of the gp120 antigen of HIV-1 to the CD4 receptor and monoclonal antibodies

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2023
Full text manuscript (801.5Kb)
Authors
Popović, Marko
Article (Published version)
,
Life in Silico
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Abstract
HIV-1, like other viruses, represents an open thermodynamic system. This is why it is important to know its thermodynamic properties. Virus-host interactions are performed at the membrane as antigen-receptor binding. Antigen-receptor binding represents a chemical reaction, similar to protein-ligand interactions. The driving force for antigen-receptor binding is Gibbs energy of binding. Knowing Gibbs energy of binding, it is possible to estimate the rate of virus binding and entry into host cells. In this paper, binding equilibrium constants and standard Gibbs energies of binding between the HIV-1 gp120 antigen and the CD4 receptor have been reported at 4 °C, 22 °C and 37 °C.
Keywords:
Biothermodynamics of viruses / HIV-1 / Binding constant / Gibbs energy of binding / Antigen-receptor binding
Source:
Life in Silico, 2023, 1, 1, 8-12
Publisher:
  • Bektas Tepe Publications
[ Google Scholar ]
Handle
https://hdl.handle.net/21.15107/rcub_cer_6136
URI
https://life-insilico.com/index.php/pub/article/view/2
https://cer.ihtm.bg.ac.rs/handle/123456789/6136
Collections
  • Radovi istraživača pre dolaska u IHTM / Researchers' papers before joining ICTM
Institution/Community
IHTM
TY  - JOUR
AU  - Popović, Marko
PY  - 2023
UR  - https://life-insilico.com/index.php/pub/article/view/2
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/6136
AB  - HIV-1, like other viruses, represents an open thermodynamic system. This is why it is important to know its thermodynamic properties. Virus-host interactions are performed at the membrane as antigen-receptor binding. Antigen-receptor binding represents a chemical reaction, similar to protein-ligand interactions. The driving force for antigen-receptor binding is Gibbs energy of binding. Knowing Gibbs energy of binding, it is possible to estimate the rate of virus binding and entry into host cells. In this paper, binding equilibrium constants and standard Gibbs energies of binding between the HIV-1 gp120 antigen and the CD4 receptor have been reported at 4 °C, 22 °C and 37 °C.
PB  - Bektas Tepe Publications
T2  - Life in Silico
T1  - Closer look into HIV-host interactions: Standard Gibbs energy of binding of the gp120 antigen of HIV-1 to the CD4 receptor and monoclonal antibodies
VL  - 1
IS  - 1
SP  - 8
EP  - 12
UR  - https://hdl.handle.net/21.15107/rcub_cer_6136
ER  - 
@article{
author = "Popović, Marko",
year = "2023",
abstract = "HIV-1, like other viruses, represents an open thermodynamic system. This is why it is important to know its thermodynamic properties. Virus-host interactions are performed at the membrane as antigen-receptor binding. Antigen-receptor binding represents a chemical reaction, similar to protein-ligand interactions. The driving force for antigen-receptor binding is Gibbs energy of binding. Knowing Gibbs energy of binding, it is possible to estimate the rate of virus binding and entry into host cells. In this paper, binding equilibrium constants and standard Gibbs energies of binding between the HIV-1 gp120 antigen and the CD4 receptor have been reported at 4 °C, 22 °C and 37 °C.",
publisher = "Bektas Tepe Publications",
journal = "Life in Silico",
title = "Closer look into HIV-host interactions: Standard Gibbs energy of binding of the gp120 antigen of HIV-1 to the CD4 receptor and monoclonal antibodies",
volume = "1",
number = "1",
pages = "8-12",
url = "https://hdl.handle.net/21.15107/rcub_cer_6136"
}
Popović, M.. (2023). Closer look into HIV-host interactions: Standard Gibbs energy of binding of the gp120 antigen of HIV-1 to the CD4 receptor and monoclonal antibodies. in Life in Silico
Bektas Tepe Publications., 1(1), 8-12.
https://hdl.handle.net/21.15107/rcub_cer_6136
Popović M. Closer look into HIV-host interactions: Standard Gibbs energy of binding of the gp120 antigen of HIV-1 to the CD4 receptor and monoclonal antibodies. in Life in Silico. 2023;1(1):8-12.
https://hdl.handle.net/21.15107/rcub_cer_6136 .
Popović, Marko, "Closer look into HIV-host interactions: Standard Gibbs energy of binding of the gp120 antigen of HIV-1 to the CD4 receptor and monoclonal antibodies" in Life in Silico, 1, no. 1 (2023):8-12,
https://hdl.handle.net/21.15107/rcub_cer_6136 .

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