Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants
Abstract
SARS-CoV-2 virus is the cause of COVID-19 pandemic and belongs to RNA viruses, showing great tendency to mutate. Several dozens of mutations have been observed on the SARS-CoV-2 virus, during the last two years. Some of the mutated strains show a greater infectivity and are capable of suppressing the earlier strains, through interference. In this work, kinetic and thermodynamic properties were calculated for strains characterized by various numbers and locations of mutations. It was shown that mutations lead to changes in chemical composition, thermodynamic properties and infectivity. Through competition, the phenomenon of interference of various SARS-CoV-2 strains was explained, which results in suppression of the wild type by mutant strains. Standard Gibbs energy of binding and binding constant for the Omicron (B.1.1.529) strain were found to be ΔBG⁰ = −45.96 kJ/mol and KB = 1.13 ∙ 10+8 M−1, respectively.
Keywords:
Hu-1 strain / Alpha strain / Beta strain / Gamma strain / Delta strain / Omicron strainSource:
Virology, 2021, 570, 35-44Publisher:
- Elsevier
DOI: 10.1016/j.virol.2022.03.008
ISSN: 0042-6822
PubMed: 0042-6822
Scopus: 2-s2.0-85127310583
Institution/Community
IHTMTY - JOUR AU - Popović, Marko PY - 2021 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6089 AB - SARS-CoV-2 virus is the cause of COVID-19 pandemic and belongs to RNA viruses, showing great tendency to mutate. Several dozens of mutations have been observed on the SARS-CoV-2 virus, during the last two years. Some of the mutated strains show a greater infectivity and are capable of suppressing the earlier strains, through interference. In this work, kinetic and thermodynamic properties were calculated for strains characterized by various numbers and locations of mutations. It was shown that mutations lead to changes in chemical composition, thermodynamic properties and infectivity. Through competition, the phenomenon of interference of various SARS-CoV-2 strains was explained, which results in suppression of the wild type by mutant strains. Standard Gibbs energy of binding and binding constant for the Omicron (B.1.1.529) strain were found to be ΔBG⁰ = −45.96 kJ/mol and KB = 1.13 ∙ 10+8 M−1, respectively. PB - Elsevier T2 - Virology T1 - Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants VL - 570 SP - 35 EP - 44 DO - 10.1016/j.virol.2022.03.008 ER -
@article{ author = "Popović, Marko", year = "2021", abstract = "SARS-CoV-2 virus is the cause of COVID-19 pandemic and belongs to RNA viruses, showing great tendency to mutate. Several dozens of mutations have been observed on the SARS-CoV-2 virus, during the last two years. Some of the mutated strains show a greater infectivity and are capable of suppressing the earlier strains, through interference. In this work, kinetic and thermodynamic properties were calculated for strains characterized by various numbers and locations of mutations. It was shown that mutations lead to changes in chemical composition, thermodynamic properties and infectivity. Through competition, the phenomenon of interference of various SARS-CoV-2 strains was explained, which results in suppression of the wild type by mutant strains. Standard Gibbs energy of binding and binding constant for the Omicron (B.1.1.529) strain were found to be ΔBG⁰ = −45.96 kJ/mol and KB = 1.13 ∙ 10+8 M−1, respectively.", publisher = "Elsevier", journal = "Virology", title = "Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants", volume = "570", pages = "35-44", doi = "10.1016/j.virol.2022.03.008" }
Popović, M.. (2021). Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants. in Virology Elsevier., 570, 35-44. https://doi.org/10.1016/j.virol.2022.03.008
Popović M. Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants. in Virology. 2021;570:35-44. doi:10.1016/j.virol.2022.03.008 .
Popović, Marko, "Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants" in Virology, 570 (2021):35-44, https://doi.org/10.1016/j.virol.2022.03.008 . .
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