Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive Interactions
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Biological, physical and chemical interaction between one (or more) microorganisms and a host organism, causing host cell damage, represents an infection. Infection of a plant, animal or microorganism with a virus can prevent infection with another virus. This phenomenon is known as viral interference. Viral interference is shown to result from two types of interactions, one taking place at the cell surface and the other intracellularly. Various viruses use different receptors to enter the same host cell, but various strains of one virus use the same receptor. The rate of virus–receptor binding can vary between different viruses attacking the same host, allowing interference or coinfection. The outcome of the virus–virus–host competition is determined by the Gibbs energies of binding and growth of the competing viruses and host. The virus with a more negative Gibbs energy of binding to the host cell receptor will enter the host first, while the virus characterized by a more negative Gi...bbs energy of growth will overtake the host metabolic machine and dominate. Once in the host cell, the multiplication machinery is shared by the competing viruses. Their potential to utilize it depends on the Gibbs energy of growth. Thus, the virus with a more negative Gibbs energy of growth will dominate. Therefore, the outcome can be interference or coinfection, depending on both the attachment kinetics (susceptibility) and the intracellular multiplication machinery (permittivity). The ratios of the Gibbs energies of binding and growth of the competing viruses determine the outcome of the competition. Based on this, a predictive model of virus–virus competition is proposed.
Кључне речи:
biothermodynamics / Gibbs energy / susceptibility / permittivity / infectionИзвор:
Microorganisms, 2021, 9, 10, 2060-Издавач:
- MDPI
DOI: 10.3390/microorganisms9102060
ISSN: 2076-2607
PubMed: 34683381
Scopus: 2-s2.0-85115992205
Институција/група
IHTMTY - JOUR AU - Popović, Marko AU - Minceva, Mirjana PY - 2021 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6068 AB - Biological, physical and chemical interaction between one (or more) microorganisms and a host organism, causing host cell damage, represents an infection. Infection of a plant, animal or microorganism with a virus can prevent infection with another virus. This phenomenon is known as viral interference. Viral interference is shown to result from two types of interactions, one taking place at the cell surface and the other intracellularly. Various viruses use different receptors to enter the same host cell, but various strains of one virus use the same receptor. The rate of virus–receptor binding can vary between different viruses attacking the same host, allowing interference or coinfection. The outcome of the virus–virus–host competition is determined by the Gibbs energies of binding and growth of the competing viruses and host. The virus with a more negative Gibbs energy of binding to the host cell receptor will enter the host first, while the virus characterized by a more negative Gibbs energy of growth will overtake the host metabolic machine and dominate. Once in the host cell, the multiplication machinery is shared by the competing viruses. Their potential to utilize it depends on the Gibbs energy of growth. Thus, the virus with a more negative Gibbs energy of growth will dominate. Therefore, the outcome can be interference or coinfection, depending on both the attachment kinetics (susceptibility) and the intracellular multiplication machinery (permittivity). The ratios of the Gibbs energies of binding and growth of the competing viruses determine the outcome of the competition. Based on this, a predictive model of virus–virus competition is proposed. PB - MDPI T2 - Microorganisms T1 - Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive Interactions VL - 9 IS - 10 SP - 2060 DO - 10.3390/microorganisms9102060 ER -
@article{ author = "Popović, Marko and Minceva, Mirjana", year = "2021", abstract = "Biological, physical and chemical interaction between one (or more) microorganisms and a host organism, causing host cell damage, represents an infection. Infection of a plant, animal or microorganism with a virus can prevent infection with another virus. This phenomenon is known as viral interference. Viral interference is shown to result from two types of interactions, one taking place at the cell surface and the other intracellularly. Various viruses use different receptors to enter the same host cell, but various strains of one virus use the same receptor. The rate of virus–receptor binding can vary between different viruses attacking the same host, allowing interference or coinfection. The outcome of the virus–virus–host competition is determined by the Gibbs energies of binding and growth of the competing viruses and host. The virus with a more negative Gibbs energy of binding to the host cell receptor will enter the host first, while the virus characterized by a more negative Gibbs energy of growth will overtake the host metabolic machine and dominate. Once in the host cell, the multiplication machinery is shared by the competing viruses. Their potential to utilize it depends on the Gibbs energy of growth. Thus, the virus with a more negative Gibbs energy of growth will dominate. Therefore, the outcome can be interference or coinfection, depending on both the attachment kinetics (susceptibility) and the intracellular multiplication machinery (permittivity). The ratios of the Gibbs energies of binding and growth of the competing viruses determine the outcome of the competition. Based on this, a predictive model of virus–virus competition is proposed.", publisher = "MDPI", journal = "Microorganisms", title = "Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive Interactions", volume = "9", number = "10", pages = "2060", doi = "10.3390/microorganisms9102060" }
Popović, M.,& Minceva, M.. (2021). Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive Interactions. in Microorganisms MDPI., 9(10), 2060. https://doi.org/10.3390/microorganisms9102060
Popović M, Minceva M. Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive Interactions. in Microorganisms. 2021;9(10):2060. doi:10.3390/microorganisms9102060 .
Popović, Marko, Minceva, Mirjana, "Coinfection and Interference Phenomena Are the Results of Multiple Thermodynamic Competitive Interactions" in Microorganisms, 9, no. 10 (2021):2060, https://doi.org/10.3390/microorganisms9102060 . .