Strain wars 4 - Darwinian evolution through Gibbs’ glasses: Gibbs energies of binding and growth explain evolution of SARS-CoV-2 from Hu-1 to BA.2
Само за регистроване кориснике
2022
Чланак у часопису (Објављена верзија)
,
Elsevier Inc.
Метаподаци
Приказ свих података о документуАпстракт
All processes in nature are driven by negative Gibbs energy. Gibbs energy is used by various viruses and their strains to hijack host cell metabolic machinery. The analysis was made by using the atom counting method to obtain elemental compositions and Gibbs energy of growth of the BA.2 strain of SARS-CoV-2. Moreover, Gibbs energy of binding was determined for the BA.2 strain. The properties of BA.2 were compared to those of Hu-1, Delta and Omicron strains. It is concluded that SARS-CoV-2 has evolved by making its Gibbs energy of binding more negative. Hence, it seems that the change in Gibbs energy of binding plays the major role in SARS-CoV-2 evolution. Therefore, Gibbs energy difference between various strains represents the possible mechanism of Darwinian evolution of viruses. In particular, a virus evolves through mutations, resulting in change in information content, elemental composition, increase in infectivity and decrease in pathogenicity.
Кључне речи:
Empirical formula / Enthalpy / Entropy / Binding affinity / Driving force / EvolutionИзвор:
Virology, 2022, 575, 36-42Издавач:
- Elsevier
DOI: 10.1016/j.virol.2022.08.009
ISSN: 0042-6822
PubMed: 36057159
Scopus: 2-s2.0-85137096377
Институција/група
IHTMTY - JOUR AU - Popović, Marko PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6066 AB - All processes in nature are driven by negative Gibbs energy. Gibbs energy is used by various viruses and their strains to hijack host cell metabolic machinery. The analysis was made by using the atom counting method to obtain elemental compositions and Gibbs energy of growth of the BA.2 strain of SARS-CoV-2. Moreover, Gibbs energy of binding was determined for the BA.2 strain. The properties of BA.2 were compared to those of Hu-1, Delta and Omicron strains. It is concluded that SARS-CoV-2 has evolved by making its Gibbs energy of binding more negative. Hence, it seems that the change in Gibbs energy of binding plays the major role in SARS-CoV-2 evolution. Therefore, Gibbs energy difference between various strains represents the possible mechanism of Darwinian evolution of viruses. In particular, a virus evolves through mutations, resulting in change in information content, elemental composition, increase in infectivity and decrease in pathogenicity. PB - Elsevier T2 - Virology T1 - Strain wars 4 - Darwinian evolution through Gibbs’ glasses: Gibbs energies of binding and growth explain evolution of SARS-CoV-2 from Hu-1 to BA.2 VL - 575 SP - 36 EP - 42 DO - 10.1016/j.virol.2022.08.009 ER -
@article{ author = "Popović, Marko", year = "2022", abstract = "All processes in nature are driven by negative Gibbs energy. Gibbs energy is used by various viruses and their strains to hijack host cell metabolic machinery. The analysis was made by using the atom counting method to obtain elemental compositions and Gibbs energy of growth of the BA.2 strain of SARS-CoV-2. Moreover, Gibbs energy of binding was determined for the BA.2 strain. The properties of BA.2 were compared to those of Hu-1, Delta and Omicron strains. It is concluded that SARS-CoV-2 has evolved by making its Gibbs energy of binding more negative. Hence, it seems that the change in Gibbs energy of binding plays the major role in SARS-CoV-2 evolution. Therefore, Gibbs energy difference between various strains represents the possible mechanism of Darwinian evolution of viruses. In particular, a virus evolves through mutations, resulting in change in information content, elemental composition, increase in infectivity and decrease in pathogenicity.", publisher = "Elsevier", journal = "Virology", title = "Strain wars 4 - Darwinian evolution through Gibbs’ glasses: Gibbs energies of binding and growth explain evolution of SARS-CoV-2 from Hu-1 to BA.2", volume = "575", pages = "36-42", doi = "10.1016/j.virol.2022.08.009" }
Popović, M.. (2022). Strain wars 4 - Darwinian evolution through Gibbs’ glasses: Gibbs energies of binding and growth explain evolution of SARS-CoV-2 from Hu-1 to BA.2. in Virology Elsevier., 575, 36-42. https://doi.org/10.1016/j.virol.2022.08.009
Popović M. Strain wars 4 - Darwinian evolution through Gibbs’ glasses: Gibbs energies of binding and growth explain evolution of SARS-CoV-2 from Hu-1 to BA.2. in Virology. 2022;575:36-42. doi:10.1016/j.virol.2022.08.009 .
Popović, Marko, "Strain wars 4 - Darwinian evolution through Gibbs’ glasses: Gibbs energies of binding and growth explain evolution of SARS-CoV-2 from Hu-1 to BA.2" in Virology, 575 (2022):36-42, https://doi.org/10.1016/j.virol.2022.08.009 . .