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dc.creatorPopović, Marko
dc.date.accessioned2023-04-12T19:54:47Z
dc.date.available2023-04-12T19:54:47Z
dc.date.issued2022
dc.identifier.issn2352-3522
dc.identifier.urihttps://cer.ihtm.bg.ac.rs/handle/123456789/6053
dc.description.abstractDuring the COVID-19 pandemic, many statistical and epidemiological studies have been published, trying to predict the future development of the SARS-CoV-2 pandemic. However, it would be beneficial to have a specific, mechanistic biophysical model, based on the driving forces of processes performed during virus-host interactions and fundamental laws of nature, allowing prediction of future evolution of SARS-CoV-2 and other viruses. In this paper, an attempt was made to predict the development of the pandemic, based on biothermodynamic parameters: Gibbs energy of binding and Gibbs energy of growth. Based on analysis of biothermodynamic parameters of various variants of SARS-CoV-2, SARS-CoV and MERS-CoV that appeared during evolution, an attempt was made to predict the future directions of evolution of SARS-CoV-2 and potential occurrence of new strains that could lead to new pandemic waves. Possible new mutations that could appear in the future could lead to changes in chemical composition, biothermodynamic properties (driving forces of new virus strains) and biological properties of SARS CoV-2 that represent a risk for humanity.sr
dc.language.isoensr
dc.publisherElseviersr
dc.rightsrestrictedAccesssr
dc.sourceMicrobial Risk Analysissr
dc.subjectGibbs energy of bindingsr
dc.subjectGibbs energy of growthsr
dc.subjectSARS-CoVsr
dc.subjectMERS-CoVsr
dc.subjectMechanistic modelsr
dc.titleBeyond COVID-19: Do biothermodynamic properties allow predicting the future evolution of SARS-CoV-2 variants?sr
dc.typearticlesr
dc.rights.licenseARRsr
dc.rights.holderElseviersr
dc.citation.volume22
dc.citation.spage100232
dc.citation.rankM23~
dc.identifier.pmid36061411
dc.identifier.doi10.1016/j.mran.2022.100232
dc.identifier.scopus2-s2.0-85137296331
dc.type.versionpublishedVersionsr


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