Why doesn’t Ebola virus cause pandemics like SARS-CoV-2?
Само за регистроване кориснике
2022
Чланак у часопису (Објављена верзија)
,
Elsevier
Метаподаци
Приказ свих података о документуАпстракт
Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host interaction) could help us to understand pathogenesis of Ebola virus disease (earlier known as the Ebola hemorrhagic fever). In this paper for the first time the empirical formula, thermodynamic properties of biosynthesis (including the driving force of virus multiplication in the susceptible host), binding constant and thermodynamic properties of binding are reported. Thermodynamic data for Ebola virus were compared with data for SARS-CoV-2 to explain why SARS-CoV-2 has caused a pandemic, while Ebola remains on local epidemic level. The empirical formula of the Ebola virus was found to be CH1.569O0.3281N0.2786P0.00173S0.00258. Standard Gibbs energy of biosynthesis of the Ebola virus nucleoc...apsid is -151.59 kJ/C-mol.
Кључне речи:
Bundibugyo GP / Zaire GP / hTIM-1 / Gibbs energy of binding / Binding constant / Gibbs energy of biosynthesisИзвор:
Microbial Risk Analysis, 2022, 22, 100236-Издавач:
- Elsevier
DOI: 10.1016/j.mran.2022.100236
ISSN: 2352-3522
PubMed: 36312211
Scopus: 2-s2.0-85140902289
Институција/група
IHTMTY - JOUR AU - Popović, Marko PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/6051 AB - Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host interaction) could help us to understand pathogenesis of Ebola virus disease (earlier known as the Ebola hemorrhagic fever). In this paper for the first time the empirical formula, thermodynamic properties of biosynthesis (including the driving force of virus multiplication in the susceptible host), binding constant and thermodynamic properties of binding are reported. Thermodynamic data for Ebola virus were compared with data for SARS-CoV-2 to explain why SARS-CoV-2 has caused a pandemic, while Ebola remains on local epidemic level. The empirical formula of the Ebola virus was found to be CH1.569O0.3281N0.2786P0.00173S0.00258. Standard Gibbs energy of biosynthesis of the Ebola virus nucleocapsid is -151.59 kJ/C-mol. PB - Elsevier T2 - Microbial Risk Analysis T1 - Why doesn’t Ebola virus cause pandemics like SARS-CoV-2? VL - 22 SP - 100236 DO - 10.1016/j.mran.2022.100236 ER -
@article{ author = "Popović, Marko", year = "2022", abstract = "Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral diseases. However, Ebola virus has never extensively spread in human population and never have led to a pandemic. Why? The mechanistic biophysical model revealing the biothermodynamic background of virus-host interaction) could help us to understand pathogenesis of Ebola virus disease (earlier known as the Ebola hemorrhagic fever). In this paper for the first time the empirical formula, thermodynamic properties of biosynthesis (including the driving force of virus multiplication in the susceptible host), binding constant and thermodynamic properties of binding are reported. Thermodynamic data for Ebola virus were compared with data for SARS-CoV-2 to explain why SARS-CoV-2 has caused a pandemic, while Ebola remains on local epidemic level. The empirical formula of the Ebola virus was found to be CH1.569O0.3281N0.2786P0.00173S0.00258. Standard Gibbs energy of biosynthesis of the Ebola virus nucleocapsid is -151.59 kJ/C-mol.", publisher = "Elsevier", journal = "Microbial Risk Analysis", title = "Why doesn’t Ebola virus cause pandemics like SARS-CoV-2?", volume = "22", pages = "100236", doi = "10.1016/j.mran.2022.100236" }
Popović, M.. (2022). Why doesn’t Ebola virus cause pandemics like SARS-CoV-2?. in Microbial Risk Analysis Elsevier., 22, 100236. https://doi.org/10.1016/j.mran.2022.100236
Popović M. Why doesn’t Ebola virus cause pandemics like SARS-CoV-2?. in Microbial Risk Analysis. 2022;22:100236. doi:10.1016/j.mran.2022.100236 .
Popović, Marko, "Why doesn’t Ebola virus cause pandemics like SARS-CoV-2?" in Microbial Risk Analysis, 22 (2022):100236, https://doi.org/10.1016/j.mran.2022.100236 . .