In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and 1H, 13C and 15N NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans.
TY - JOUR
AU - Mitić, Dragana
AU - Milenković, Marina
AU - Milosavljević, Slobodan
AU - Gođevac, Dejan
AU - Miodragović, Zoran
AU - Anđelković, Katarina
AU - Miodragović, D.
PY - 2009
UR - https://cer.ihtm.bg.ac.rs/handle/123456789/594
AB - In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and 1H, 13C and 15N NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans.
PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2 - European Journal of Medicinal Chemistry
T1 - Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine
VL - 44
IS - 4
SP - 1537
EP - 1544
DO - 10.1016/j.ejmech.2008.07.017
ER -
@article{
author = "Mitić, Dragana and Milenković, Marina and Milosavljević, Slobodan and Gođevac, Dejan and Miodragović, Zoran and Anđelković, Katarina and Miodragović, D.",
year = "2009",
abstract = "In this paper the first complexes of M2+ ions (M2+ = Zn2+, Cd2+ and Co2+) with N-benzyloxycarbonyl-S-phenylalaninato ligand (1-3) are described. The new complexes were characterized by means of elemental analysis, IR and UV-vis spectroscopy, molar conductivity measurements and 1H, 13C and 15N NMR spectroscopy (1D and 2D). The Co(II) complex adopts an octahedral geometry, and the Zn(II) and Cd(II) complexes adopt a tetrahedral one. For the first time, the antimicrobial activity of N-benzyloxycarbonyl-S-phenylalaninato ligand (N-Boc-S-phe) and the complexes 1-3 was investigated against Gram-positive: Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis and Gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and two strains of the yeast Candida albicans. It was shown that the complexes were effective against most strains. The best activity was detected against the yeast C. albicans.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine",
volume = "44",
number = "4",
pages = "1537-1544",
doi = "10.1016/j.ejmech.2008.07.017"
}
Mitić, D., Milenković, M., Milosavljević, S., Gođevac, D., Miodragović, Z., Anđelković, K.,& Miodragović, D.. (2009). Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 44(4), 1537-1544.
https://doi.org/10.1016/j.ejmech.2008.07.017
Mitić D, Milenković M, Milosavljević S, Gođevac D, Miodragović Z, Anđelković K, Miodragović D. Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine. in European Journal of Medicinal Chemistry. 2009;44(4):1537-1544.
doi:10.1016/j.ejmech.2008.07.017 .
Mitić, Dragana, Milenković, Marina, Milosavljević, Slobodan, Gođevac, Dejan, Miodragović, Zoran, Anđelković, Katarina, Miodragović, D., "Synthesis, characterization and antimicrobial activity of Co(II), Zn(II) and Cd(II) complexes with N-benzyloxycarbonyl-S-phenylalanine" in European Journal of Medicinal Chemistry, 44, no. 4 (2009):1537-1544,
https://doi.org/10.1016/j.ejmech.2008.07.017 . .
