Structure-activity relationship, docking analysis and ADME properties of newly designed, potent serotonin 5HT1a receptor ligands
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2022
Authors
Jevtić, Ivana
Andrić, Deana

Penjišević, Jelena

Šukalović, Vladimir

Dukic-Stefanovic, Sladjana
Kostić-Rajačić, Slađana

Conference object (Published version)

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Serotonin 5HT1a receptors belongs to a class G-protein coupled receptors and it is widely recognized as one of the targets for treating neurological disorders such depression and schizophrenia. N-arylpiperazine structural motif is present in many compounds with pronounced 5HT1a activity including recently approved aripiprazole for the treatment of the major depressive disorder.
Keywords:
Serotonin-1A receptor / ADMESource:
Book of abstracts - EFMC-YMCS-Young Medicinal Chemists' Symposium, September 8-9, 2022, Nice, France, 2022, 66-66Publisher:
- European Federation for Medicinal chemistry and Chemical biology (EFMC)
Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-200026)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
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IHTMTY - CONF AU - Jevtić, Ivana AU - Andrić, Deana AU - Penjišević, Jelena AU - Šukalović, Vladimir AU - Dukic-Stefanovic, Sladjana AU - Kostić-Rajačić, Slađana PY - 2022 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/5851 AB - Serotonin 5HT1a receptors belongs to a class G-protein coupled receptors and it is widely recognized as one of the targets for treating neurological disorders such depression and schizophrenia. N-arylpiperazine structural motif is present in many compounds with pronounced 5HT1a activity including recently approved aripiprazole for the treatment of the major depressive disorder. PB - European Federation for Medicinal chemistry and Chemical biology (EFMC) C3 - Book of abstracts - EFMC-YMCS-Young Medicinal Chemists' Symposium, September 8-9, 2022, Nice, France T1 - Structure-activity relationship, docking analysis and ADME properties of newly designed, potent serotonin 5HT1a receptor ligands SP - 66 EP - 66 UR - https://hdl.handle.net/21.15107/rcub_cer_5851 ER -
@conference{ author = "Jevtić, Ivana and Andrić, Deana and Penjišević, Jelena and Šukalović, Vladimir and Dukic-Stefanovic, Sladjana and Kostić-Rajačić, Slađana", year = "2022", abstract = "Serotonin 5HT1a receptors belongs to a class G-protein coupled receptors and it is widely recognized as one of the targets for treating neurological disorders such depression and schizophrenia. N-arylpiperazine structural motif is present in many compounds with pronounced 5HT1a activity including recently approved aripiprazole for the treatment of the major depressive disorder.", publisher = "European Federation for Medicinal chemistry and Chemical biology (EFMC)", journal = "Book of abstracts - EFMC-YMCS-Young Medicinal Chemists' Symposium, September 8-9, 2022, Nice, France", title = "Structure-activity relationship, docking analysis and ADME properties of newly designed, potent serotonin 5HT1a receptor ligands", pages = "66-66", url = "https://hdl.handle.net/21.15107/rcub_cer_5851" }
Jevtić, I., Andrić, D., Penjišević, J., Šukalović, V., Dukic-Stefanovic, S.,& Kostić-Rajačić, S.. (2022). Structure-activity relationship, docking analysis and ADME properties of newly designed, potent serotonin 5HT1a receptor ligands. in Book of abstracts - EFMC-YMCS-Young Medicinal Chemists' Symposium, September 8-9, 2022, Nice, France European Federation for Medicinal chemistry and Chemical biology (EFMC)., 66-66. https://hdl.handle.net/21.15107/rcub_cer_5851
Jevtić I, Andrić D, Penjišević J, Šukalović V, Dukic-Stefanovic S, Kostić-Rajačić S. Structure-activity relationship, docking analysis and ADME properties of newly designed, potent serotonin 5HT1a receptor ligands. in Book of abstracts - EFMC-YMCS-Young Medicinal Chemists' Symposium, September 8-9, 2022, Nice, France. 2022;:66-66. https://hdl.handle.net/21.15107/rcub_cer_5851 .
Jevtić, Ivana, Andrić, Deana, Penjišević, Jelena, Šukalović, Vladimir, Dukic-Stefanovic, Sladjana, Kostić-Rajačić, Slađana, "Structure-activity relationship, docking analysis and ADME properties of newly designed, potent serotonin 5HT1a receptor ligands" in Book of abstracts - EFMC-YMCS-Young Medicinal Chemists' Symposium, September 8-9, 2022, Nice, France (2022):66-66, https://hdl.handle.net/21.15107/rcub_cer_5851 .