Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes
Authorized Users Only
2009
Authors
Vuković, G.Marinković, Aleksandar D.

Obradović, Maja

Radmilović, V.
Čolić, M.
Aleksić, Radoslav
Uskoković, Petar S.

Article (Published version)

Metadata
Show full item recordAbstract
Surface functionalization of multi-walled carbon nanotubes (MWCNTs), with amino groups via chemical modification of carboxyl groups introduced on the nanotube surface, using O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (N-HATU) and N,N-diisopropylethylamine (DIEA) is reported. The N-HATU coupling agent provides faster reaction rate and the reaction occurs at lower temperature compared to amidation and acylation-amidation chemistry. The amines, 1,6-hexanediamine (HDA), diethylenetriamine (DETA), triethylenetetramine (TETA) and 1,4-phenylenediamine (PDA) were used. The resulting materials were characterized with different techniques such as FTIR, XRD, elemental analysis, TGA, TEM, UV-vis spectroscopy and cyclic voltammetry. MWCNTs functionalized with PDA posses the best dispersibility and electron transfer properties in comparison to the others amines. Functionalized MWCNTs, at the concentrations between 1 and 50 μg ml-1, were not cytotoxic for the fibrobla...st L929 cell line. However, the concentrations of MWCNTs higher of 10 μg ml-1 reduced cell growth and this effect correlated positively with the degree of their uptake by L929 cells.
Keywords:
Amino-functionalization / Carbon nanotubes / Cyclic voltammetry / cytotoxicitySource:
Applied Surface Science, 2009, 255, 18, 8067-8075Publisher:
- Elsevier
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1016/j.apsusc.2009.05.016
ISSN: 0169-4332
WoS: 000267469500039
Scopus: 2-s2.0-67649097074
Collections
Institution/Community
IHTMTY - JOUR AU - Vuković, G. AU - Marinković, Aleksandar D. AU - Obradović, Maja AU - Radmilović, V. AU - Čolić, M. AU - Aleksić, Radoslav AU - Uskoković, Petar S. PY - 2009 UR - https://cer.ihtm.bg.ac.rs/handle/123456789/584 AB - Surface functionalization of multi-walled carbon nanotubes (MWCNTs), with amino groups via chemical modification of carboxyl groups introduced on the nanotube surface, using O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (N-HATU) and N,N-diisopropylethylamine (DIEA) is reported. The N-HATU coupling agent provides faster reaction rate and the reaction occurs at lower temperature compared to amidation and acylation-amidation chemistry. The amines, 1,6-hexanediamine (HDA), diethylenetriamine (DETA), triethylenetetramine (TETA) and 1,4-phenylenediamine (PDA) were used. The resulting materials were characterized with different techniques such as FTIR, XRD, elemental analysis, TGA, TEM, UV-vis spectroscopy and cyclic voltammetry. MWCNTs functionalized with PDA posses the best dispersibility and electron transfer properties in comparison to the others amines. Functionalized MWCNTs, at the concentrations between 1 and 50 μg ml-1, were not cytotoxic for the fibroblast L929 cell line. However, the concentrations of MWCNTs higher of 10 μg ml-1 reduced cell growth and this effect correlated positively with the degree of their uptake by L929 cells. PB - Elsevier T2 - Applied Surface Science T1 - Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes VL - 255 IS - 18 SP - 8067 EP - 8075 DO - 10.1016/j.apsusc.2009.05.016 ER -
@article{ author = "Vuković, G. and Marinković, Aleksandar D. and Obradović, Maja and Radmilović, V. and Čolić, M. and Aleksić, Radoslav and Uskoković, Petar S.", year = "2009", abstract = "Surface functionalization of multi-walled carbon nanotubes (MWCNTs), with amino groups via chemical modification of carboxyl groups introduced on the nanotube surface, using O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (N-HATU) and N,N-diisopropylethylamine (DIEA) is reported. The N-HATU coupling agent provides faster reaction rate and the reaction occurs at lower temperature compared to amidation and acylation-amidation chemistry. The amines, 1,6-hexanediamine (HDA), diethylenetriamine (DETA), triethylenetetramine (TETA) and 1,4-phenylenediamine (PDA) were used. The resulting materials were characterized with different techniques such as FTIR, XRD, elemental analysis, TGA, TEM, UV-vis spectroscopy and cyclic voltammetry. MWCNTs functionalized with PDA posses the best dispersibility and electron transfer properties in comparison to the others amines. Functionalized MWCNTs, at the concentrations between 1 and 50 μg ml-1, were not cytotoxic for the fibroblast L929 cell line. However, the concentrations of MWCNTs higher of 10 μg ml-1 reduced cell growth and this effect correlated positively with the degree of their uptake by L929 cells.", publisher = "Elsevier", journal = "Applied Surface Science", title = "Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes", volume = "255", number = "18", pages = "8067-8075", doi = "10.1016/j.apsusc.2009.05.016" }
Vuković, G., Marinković, A. D., Obradović, M., Radmilović, V., Čolić, M., Aleksić, R.,& Uskoković, P. S.. (2009). Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes. in Applied Surface Science Elsevier., 255(18), 8067-8075. https://doi.org/10.1016/j.apsusc.2009.05.016
Vuković G, Marinković AD, Obradović M, Radmilović V, Čolić M, Aleksić R, Uskoković PS. Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes. in Applied Surface Science. 2009;255(18):8067-8075. doi:10.1016/j.apsusc.2009.05.016 .
Vuković, G., Marinković, Aleksandar D., Obradović, Maja, Radmilović, V., Čolić, M., Aleksić, Radoslav, Uskoković, Petar S., "Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes" in Applied Surface Science, 255, no. 18 (2009):8067-8075, https://doi.org/10.1016/j.apsusc.2009.05.016 . .